Evidence map›Paper›PMID 26371148›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015

Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.

Lawrence J Solin, Robert Gray, Lorie L Hughes, William C Wood, Mary Ann Lowen, Sunil S Badve, Frederick L Baehner, James N Ingle, Edith A Perez, Abram Recht and 2 more

Abstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Prognostic and Predictive Value of HER2 Expression in Ductal Carcinoma In Situ: Results from the UK/ANZ DCIS Randomized Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Lawrence J SolinLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY. solin@einstein.edu.
Robert GrayLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.
Lorie L HughesLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.
William C WoodLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.
Mary Ann LowenLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.
Sunil S BadveLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.
Frederick L BaehnerLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.
James N IngleLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.
Edith A PerezLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.
Abram RechtLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.
Joseph A SparanoLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.
Nancy E DavidsonLawrence J. Solin, Albert Einstein Healthcare Network, Philadelphia; Nancy E. Davidson, University of Pittsburgh, Pittsburgh, PA; Robert Gray, Dana-Farber Cancer Institute; Abram Recht, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston; Mary Ann Lowen, Baystate Medical Center, Springfield, MA; Lorie L. Hughes, Harris Radiation Therapy Center at Gordon Hospital, Calhoun; William C. Wood, Emory University, Atlanta, GA; Sunil S. Badve, Indiana University, Indianapolis, IN; Frederick L. Baehner, University of California, San Francisco, San Francisco, CA; James N. Ingle, Mayo Clinic, Rochester, MN; Edith A. Perez, Mayo Clinic, Jacksonville, FL; and Joseph A. Sparano, Montefiore Medical Center, Bronx, NY.

Funding

ECOG-ACRIN NCORP Research Base - TMISTUG1CA189828 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$199.7M
Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer · 2014 to 2026
$167.6M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
ECOG OPERATIONS OFFICE (IBCSG)U10CA021115 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI COMIS, ROBERT L · 1985 to 2013
$132.6M
Statistics CoreU10CA180794 · NCI · DANA-FARBER CANCER INST · PI PAUL J CATALANO, CONSTANTINE A. GATSONIS · 2014 to 2026
$111.2M
TRANSLATIONAL RESEARCHU10CA025224 · NCI · MAYO CLINIC ROCHESTER · PI BUCKNER, JAN C · 1985 to 2013
$85.0M
ECOG-ACRIN Biospecimen Bank to Support NCTNU24CA196172 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI STANLEY R. HAMILTON, Scott D Jewell · 2015 to 2026
$41.1M
Therapuetic Immune Targeting of EphA2 Expressed by Melanoma & Its Tumor-AssociateP50CA121973 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KIRKWOOD, JOHN MUNN · 2008 to 2018
$22.9M
Montefiore Academic Community NCORP ProgramUG1CA189859 · NCI · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI Balazs Halmos, Della Makower · 2014 to 2026
$10.8M
NCI NCTN-Network Lead Academic Participating Site at UPMC Hillman Cancer CenterUG1CA233184 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ADAM M BRUFSKY, John Munn Kirkwood · 2019 to 2026
$7.7M
NCI NCTN-Network Lead Academic Site at UPCIU10CA180844 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRUFSKY, ADAM M, EDWARDS, ROBERT PAGE · 2014 to 2018
$4.5M
Johns Hopkins University NCTN Lead Academic Site ProgramU10CA180802 · NCI · JOHNS HOPKINS UNIVERSITY · PI ARMSTRONG, DEBORAH K, BRAHMER, JULIE RENEE · 2014 to 2018
$3.3M
NCI NIH HHS CA180794NCI NIH HHS CA180795NCI NIH HHS CA180802NCI NIH HHS CA180820NCI NIH HHS CA180844NCI NIH HHS CA180864NCI NIH HHS CA189859NCI NIH HHS CA25224NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA121973NCI NIH HHS U10 CA021115NCI NIH HHS U10 CA025224NCI NIH HHS U10 CA180794NCI NIH HHS U10 CA180795NCI NIH HHS U10 CA180802NCI NIH HHS U10 CA180820NCI NIH HHS U10 CA180844NCI NIH HHS U10 CA180864NCI NIH HHS U24 CA196172NCI NIH HHS UG1 CA189828NCI NIH HHS UG1 CA189859NCI NIH HHS UG1 CA233184
6 · The paper itself

Abstract

purposeTo determine the 12-year risk of developing an ipsilateral breast event (IBE) for women with ductal carcinoma in situ (DCIS) of the breast treated with surgical excision (lumpectomy) without radiation. PATIENTS AND

methodsA prospective clinical trial was performed for women with DCIS who were selected for low-risk clinical and pathologic characteristics. Patients were enrolled onto one of two study cohorts (not randomly assigned): cohort 1: low- or intermediate-grade DCIS, tumor size 2.5 cm or smaller (n = 561); or cohort 2: high-grade DCIS, tumor size 1 cm or smaller (n = 104). Protocol specifications included excision of the DCIS tumor with a minimum negative margin width of at least 3 mm. Tamoxifen (not randomly assigned) was given to 30% of the patients. An IBE was defined as local recurrence of DCIS or invasive carcinoma in the treated breast. Median follow-up time was 12.3 years.

resultsThere were 99 IBEs, of which 51 (52%) were invasive. The IBE and invasive IBE rates increased over time in both cohorts. The 12-year rates of developing an IBE were 14.4% for cohort 1 and 24.6% for cohort 2 (P = .003). The 12-year rates of developing an invasive IBE were 7.5% and 13.4%, respectively (P = .08). On multivariable analysis, study cohort and tumor size were both significantly associated with developing an IBE (P = .009 and P = .03, respectively).

conclusionFor patients with DCIS selected for favorable clinical and pathologic characteristics and treated with excision without radiation, the risks of developing an IBE and an invasive IBE increased through 12 years of follow-up, without plateau. These data help inform the treatment decision-making process for patients and their physicians.

Indexed as

AdultAgedBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingFemaleFollow-Up StudiesHumansImmunohistochemistryKaplan-Meier EstimateMastectomy, SegmentalMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingProportional Hazards ModelsTamoxifen

Identifiers

PMID26371148
PMCPMC4652014

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.