ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015
Improved Outcomes After Autologous Hematopoietic Cell Transplantation for Light Chain Amyloidosis: A Center for International Blood and Marrow Transplant Research Study.
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In one paragraph
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 201 citations in OpenAlex.
- Indications for haematopoietic cell transplantation and CAR-T for haematological diseases, solid tumours and immune disorders: 2025 EBMT practice recommendations.Bone marrow transplantation · 2025Guideline
- Autologous stem cell transplantation in patients with AL amyloidosis with impaired renal function.Bone marrow transplantation · 2019Trial
- Bortezomib-based induction followed by stem cell transplantation in light chain amyloidosis: results of the multicenter HOVON 104 trial.Haematologica · 2019Trial
- Determinants of Long-Term Benefit From High Dose Melphalan With Autologous Stem Cell Transplant in AL Amyloidosis.American journal of hematology · 2026Article
- Management of relapsed/refractory AL amyloidosis.Blood advances · 2026Review
- Long-term outcomes of autologous stem cell transplantation for AL amyloidosis: a 15-year experience from a Chinese referral center and a comparison of different eras.Blood cancer journal · 2026Article
- The Impact of Melphalan Conditioning and CD34American journal of hematology · 2025Article
- The pre-ASCT serum albumin and pre-ASCT dFLC are prognostic markers in renal light chain amyloidosis patients treated with autologous stem cell transplantation.Bone marrow transplantation · 2025Article
- A model for predicting day-100 stem cell transplant-related mortality in AL amyloidosis.Bone marrow transplantation · 2025Article
- Venetoclax Plus CyBorD Induction Therapy and Venetoclax Maintenance Treatment for Immunoglobulin Light Chain Amyloidosis with t(11;14) Translocation.Current oncology (Toronto, Ont.) · 2025Article
- AL Amyloidosis: Current Treatment and Outcomes.Advances in hematology · 2025Review
- Changing lanes: extending CAR T-cell therapy to high-risk plasma cell dyscrasias.Frontiers in immunology · 2025Review
- Autologous stem cell transplantation in AL amyloidosis: Muddy waters.Blood reviews · 2024Review
- Acute kidney injury during autologous stem cell transplantation in light chain amyloidosis with kidney involvement and their impact on prognosis.Bone marrow transplantation · 2024Article
- High-dose melphalan-autologous hematopoietic cell transplantation in systemic AL amyloidosis following daratumumab-based frontline therapy.Bone marrow transplantation · 2024Article
- Healthcare resource utilisation and costs associated with AL amyloidosis: a retrospective matched cohort study.Scientific reports · 2024Article
- Renal AL Amyloidosis: Updates on Diagnosis, Staging, and Management.Journal of clinical medicine · 2024Review
- Risk factors, treatments and outcomes of patients with light chain amyloidosis who relapse after autologous stem cell transplantation.Bone marrow transplantation · 2024Observational
- Treatment of AL amyloidosis in the era of novel immune and cellular therapies.Frontiers in oncology · 2024Review
- Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 2 institutions in 2 countries.
Anita D'SouzaAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Angela DispenzieriAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Baldeep WirkAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Mei-Jie ZhangAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Jiaxing HuangAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Morie A GertzAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Robert A KyleAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Shaji KumarAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Raymond L ComenzoAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Robert Peter GaleAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Hillard M LazarusAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Bipin N SavaniAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Robert F CornellAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Brendan M WeissAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Dan T VoglAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
César O FreytesAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Emma C ScottAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Heather J LandauAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Jan S MorebAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Luciano J CostaAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Muthalagu RamanathanAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Natalie S CallanderAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Rammurti T KambleAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Richard F OlssonAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Siddhartha GangulyAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Taiga NishihoriAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Tamila L Kindwall-KellerAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
William A WoodAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Tomer M MarkAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Parameswaran HariAnita D'Souza, Mei-Jie Zhang, Jiaxing Huang, and Parameswaran Hari, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin; Mei-Jie Zhang, Institute for Health and Society, Medical College of Wisconsin, Milwaukee; Natalie S. Callander, University of Wisconsin Carbone Cancer Center, Madison, WI; Angela Dispenzieri, Morie A. Gertz, Robert A. Kyle, and Shaji Kumar, Mayo Clinic, Rochester, MN; Baldeep Wirk, Seattle Cancer Care Alliance, Seattle, WA; Raymond L. Comenzo, Tufts Medical Center, Boston; Muthalagu Ramanathan, University of Massachusetts Memorial Medical Center, Worcester, MA; Robert Peter Gale, Hematology Research Centre, Imperial College London, London, United Kingdom; Hillard M. Lazarus, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH; Bipin N. Savani and Robert F. Cornell, Vanderbilt University Medical Center, Nashville, TN; Brendan M. Weiss and Dan T. Vogl, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA; César O. Freytes, South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio; Rammurti T. Kamble, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX; Emma C. Scott, Center for Hematologic Malignancies, The Knight Cancer Institute, Oregon Health and Science University, Portland, OR; Heather J. Landau, Memorial Sloan Kettering Cancer Center; Tomer M. Mark, Weill Cornell Medical College, New York, NY; Jan S. Moreb, Shands HealthCare and University of Florida, Gainesville; Taiga Nishihori, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Richard F. Olsson, Karolinska Institutet, Stockholm; Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden; Siddhartha Ganguly, University of Kansas Medical Center, Kansas City, KS; Tamila L. Kindwall-Keller, University of Virginia Health Sys
Karolinska Institutet · SEVanderbilt University · US
Funding
Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2MEasy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8MClincal and Translational Science AwardUL1TR000055 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2012 to 2015
$11.3MNCATS NIH HHS 8UL1TR000055NCATS NIH HHS UL1 TR000055NCI NIH HHS U24 CA076518NCI NIH HHS U24-CA076518NHLBI NIH HHS 5U10HL069294NHLBI NIH HHS U10 HL069294PHS HHS HHSH250201200016CPHS HHS N00014-13-1-0039PHS HHS N00014-14-1-0028
Abstract
purposeAutologous hematopoietic cell transplantation, or autotransplantation, is effective in light-chain amyloidosis (AL), but it is associated with a high risk of early mortality (EM). In a multicenter randomized comparison against oral chemotherapy, autotransplantation was associated with 24% EM. We analyzed trends in outcomes after autologous hematopoietic cell transplantation for AL in North America. PATIENTS AND
methodsBetween 1995 and 2012, 1,536 patients with AL who underwent autotransplantation at 134 centers were identified in the Center for International Blood and Marrow Transplant Research database. EM and overall survival (OS) were analyzed in three time cohorts: 1995 to 2000 (n = 140), 2001 to 2006 (n = 596), and 2007 to 2012 (n = 800). Hematologic and renal responses and factors associated with EM, relapse and/or progression, progression-free survival and OS were analyzed in more recent subgroups from 2001 to 2006 (n = 197) and from 2007 to 2012 (n = 157).
resultsMortality at 30 and 100 days progressively declined over successive time periods from 11% and 20%, respectively, in 1995 to 2000 to 5% and 11%, respectively, in 2001 to 2006, and to 3% and 5%, respectively, in 2007 to 2012. Correspondingly, 5-year OS improved from 55% in 1995 to 2000 to 61% in 2001 to 2006 and to 77% in 2007 to 2012. Hematologic response to transplantation improved in the latest cohort. Renal response rate was 32%. Centers performing more than four AL transplantations per year had superior survival outcomes. In the multivariable analysis, cardiac AL was associated with high EM and inferior progression-free survival and OS. Autotransplantation in 2007 to 2012 and use of higher dosages of melphalan were associated with a lowered relapse risk. A Karnofsky score less than 80 and creatinine levels 2 mg/m(2) or greater were associated with worsened OS.
conclusionPost-transplantation survival in AL has improved, with a dramatic reduction in early post-transplantation mortality and excellent 5-year survival. The risk-benefit ratio for autotransplantation has changed, and randomized comparison with nontransplantation approaches is again warranted.
Indexed as
Hematopoietic Stem Cell TransplantationImmunoglobulin Light ChainsAdultAgedAmyloidosisAntineoplastic Agents, AlkylatingDatabases, FactualDisease-Free SurvivalDisease ProgressionFemaleHumansKaplan-Meier EstimateKarnofsky Performance StatusMaleMelphalanMiddle AgedAntineoplastic Agents, AlkylatingImmunoglobulin Light ChainsMelphalanMyeloablative Agonists
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