SynthesisInternational journal of environmental research and public health2015
High Birth Weight Increases the Risk for Bone Tumor: A Systematic Review and Meta-Analysis.
Synthesis in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Parental and childhood exposures and the risk of retinoblastoma, hepatoblastoma, and germ cell, bone, and soft tissue tumors in children: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Adverse pregnancy outcomes and multiple cancers risk in both mother and offspring: an umbrella review of systematic reviews with meta-analyses of observational studies.BMC medicine · 2024Pooled it
- Effects of size at birth on health, growth and developmental outcomes in children up to age 18: an umbrella review.Archives of disease in childhood · 2023Pooled it
- Restricted cubic spline analysis of the association between the third-trimester triglyceride-glucose index and neonatal birthweight in pregnant women with gestational diabetes mellitus: a multicenter cohort study.BMC pregnancy and childbirth · 2026Article
- Article
- Genetically inferred birthweight, height, and puberty timing and risk of osteosarcoma.Cancer epidemiology · 2024Article
- Critical Windows of Maternal Exposure to Biothermal Stress and Birth Weight for Gestational Age in Western Australia.Environmental health perspectives · 2023Article
- Birth characteristics and risk of Ewing sarcoma.Cancer causes & control : CCC · 2023Article
- Osteosarcoma: A Surveillance, Epidemiology, and End Results program-based analysis from 1975 to 2017.Cancer · 2022Article
- The mediating effect of allostatic load on the relationship between neighborhood perceptions and depression.SSM - population health · 2020Article
- Transcriptome Analysis Identifies Novel Prognostic Genes in Osteosarcoma.Computational and mathematical methods in medicine · 2020Article
- Silencing of Long Non-Coding RNA LINC00607 Prevents Tumor Proliferation of Osteosarcoma by Acting as a Sponge of miR-607 to Downregulate E2F6.Frontiers in oncology · 2020Article
- Article
- Article
- Causal Association Between Birth Weight and Adult Diseases: Evidence From a Mendelian Randomization Analysis.Frontiers in genetics · 2019Article
- Germline and somatic genetics of osteosarcoma - connecting aetiology, biology and therapy.Nature reviews. Endocrinology · 2017Review
- Birth weight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses.BMC medicine · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been several epidemiologic studies on the relationship between high birth weight and the risk for bone tumor in the past decades. However, due to the rarity of bone tumors, the sample size of individual studies was generally too small for reliable conclusions. Therefore, we have performed a meta-analysis to pool all published data on electronic databases with the purpose to clarify the potential relationship. According to the inclusion and exclusion criteria, 18 independent studies with more than 2796 cases were included. As a result, high birth weight was found to increase the risk for bone tumor with an Odds Ratio (OR) of 1.13, with the 95% confidence interval (95% CI) ranging from 1.01 to 1.27. The OR of bone tumor for an increase of 500 gram of birth weight was 1.01 (95% CI 1.00-1.02; p = 0.048 for linear trend). Interestingly, individuals with high birth weight had a greater risk for osteosarcoma (OR = 1.22, 95% CI 1.06-1.40, p = 0.006) than those with normal birth weight. In addition, in the subgroup analysis by geographical region, elevated risk was detected among Europeans (OR = 1.14, 95% CI 1.00-1.29, p = 0.049). The present meta-analysis supported a positive association between high birth weight and bone tumor risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.