ArticleInternational journal of molecular sciences2015
Effects of Low Molecular Weight Yeast β-Glucan on Antioxidant and Immunological Activities in Mice.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 68 citations in OpenAlex.
- Coupling Carbon-Source Transport with Antioxidant Biosynthesis in Yeast: Product Diversity and Engineering Strategies.Biology · 2026Review
- Carboxymethylated β-glucan from Pichia kudriavzevii M16: structural characterization and multifunctional bioactivity.Folia microbiologica · 2026Article
- Electron Beam-Degraded β-Glucans fromPolymers · 2026Article
- Differential Safety and Lipid Control Efficacy of β-1,3/1,6-Glucan Oligosaccharides and Polysaccharides Derived FromFood science & nutrition · 2026Article
- Polyphenols and Fibre: Key Players with Antioxidant Activity in Two Extracts from Pomegranate (International journal of molecular sciences · 2025Article
- Formulation Strategies for Immunomodulatory Natural Products in 3D Tumor Spheroids and Organoids: Current Challenges and Emerging Solutions.Pharmaceutics · 2025Review
- Exploring the Properties and Application Potential of β-Glucan in Skin Care.Food science & nutrition · 2025Review
- Engineered polysaccharides for controlling innate and adaptive immune responses.Nature reviews bioengineering · 2024Article
- Investigating the Immune-Stimulating Potential of β-Glucan fromBiomolecules & therapeutics · 2024Article
- Immunomodulatory Effect and Biological Significance of β-Glucans.Pharmaceutics · 2023Review
- Antioxidant Activities and Cytotoxicity of the Regulated Calcium Oxalate Crystals on HK-2 Cells of Polysaccharides fromFoods (Basel, Switzerland) · 2023Article
- An important polysaccharide from fermentum.Food chemistry: X · 2022Review
- Fungi hijack a ubiquitous plant apoplastic endoglucanase to release a ROS scavenging β-glucan decasaccharide to subvert immune responses.The Plant cell · 2022Article
- Natural PolysaccharideNutrients · 2022Article
- Structural Characterization and Antioxidant Activity of Exopolysaccharide from Soybean Whey Fermented byFoods (Basel, Switzerland) · 2021Article
- Yeast β-Glucan Altered Intestinal Microbiome and Metabolome in Older Hens.Frontiers in microbiology · 2021Article
- Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review.Frontiers in immunology · 2020Review
- Effect of the Modifications on the Physicochemical and Biological Properties of β-Glucan-A Critical Review.Molecules (Basel, Switzerland) · 2019Review
- A Concise Review on the Molecular Structure and Function Relationship of β-Glucan.International journal of molecular sciences · 2019Review
- Fungal Exocellular (1-6)-β-d-glucan: Carboxymethylation, Characterization, and Antioxidant Activity.International journal of molecular sciences · 2019Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the antioxidant and immune effects of low molecular yeast β-glucan on mice, three sulfated glucans from Saccharomyces cerevisiae (sGSCs) with different molecular weight (MW) and degrees of sulfation (DS) were prepared. The structures of the sGSCs were analyzed through high performance liquid chromatography-gel permeation chromatography (HPLC-GPC) and Fourier transform infrared spectroscopy (FTIR). sGSC1, sGSC2, and sGSC3 had MW of 12.9, 16.5 and 19.2 kDa, respectively, and DS of 0.16, 0.24 and 0.27, respectively. In vitro and in vivo experiments were conducted to evaluate the antioxidant and immunological activities of the sGSCs. In vitro experiment, the reactive oxygen species (ROS) scavenging activities were determined. In vivo experiment, 50 male BALB/c mice were divided into five groups. The sGSC1, sGSC2 and sGSC3 treatment groups received the corresponding sGSCs at 50 mg/kg/day each. The GSC (glucans from Saccharomyces cerevisiae) treatment group received 50 mg/kg/day GSC. The normal control group received equal volume of physiological saline solution. All treatments were administered intragastrically for 14 day. Results showed that sGSC1, sGSC2 and sGSC3 can scavenge 1,1-diphenyl-2-picryl-hydrazyl (DPPH), superoxide, and hydroxyl radicals in vitro. The strength of the radical scavenging effects of the sGSCs was in the order of sGSC1 > sGSC2 > sGSC3. Oral administration of sGSC1 significantly improved serum catalase (CAT) and glutathione peroxidase (GSH-Px) activities and decreased malondialdehyde (MDA) level in mice. sGSC1 significantly improved the spleen and thymus indexes and the lymphocyte proliferation, effectively enhanced the percentage of CD4⁺ T cells, decreased the percentage of CD8⁺ T cells, and elevated the CD4⁺/CD8⁺ ratio. sGSC1 significantly promoted the secretion of IL-2 and IFN-γ. These results indicate that sGSC1 with low MW and DS has better antioxidant and immunological activities than the other sGSCs, and sGSC1 could be used as a new antioxidant and immune-enhancing agent.
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