ArticleInternational journal of molecular sciences2015
Gene Expression Variations of Red-White Skin Coloration in Common Carp (Cyprinus carpio).
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Partial Replacement of Fish Meal with Fish Scale Meal Enhances Body Color Brightness and Iridophore Development in Koi (Animals : an open access journal from MDPI · 2026Article
- Correlation between DNA methylation and transcriptomic changes in golden Asian sea bass (Lates calcarifer): An integrated approach.Journal of fish biology · 2026Article
- DNA Methylation and Transcriptome Profiling Reveal the Role of the Antioxidant Pathway and Lipid Metabolism inAntioxidants (Basel, Switzerland) · 2025Article
- A comprehensive review of current practices, challenges, and future perspectives in Koi fish (Veterinary world · 2024Review
- Analysis of the Skin and Brain Transcriptome of Normally Pigmented and Pseudo-Albino Southern Flounder (International journal of molecular sciences · 2024Article
- Genetic mapping and molecular mechanism behind color variation in the Asian vine snake.Genome biology · 2023Article
- Transcriptome analysis of skin color variation during and after overwintering of Malaysian red tilapia.Fish physiology and biochemistry · 2022Article
- Analysis of yellow mutant rainbow trout transcriptomes at different developmental stages reveals dynamic regulation of skin pigmentation genes.Scientific reports · 2022Article
- DNA Methylation Analyses Unveil a Regulatory Landscape in the Formation of Nacre Color in Pearl OysterFrontiers in genetics · 2022Article
- Pterin-based pigmentation in animals.Biology letters · 2021Article
- Transcriptome sequencing and analysis for the pigmentation of scale and skin in common carp (Cyprinus carpio).Molecular biology reports · 2021Article
- Integrated analysis of long non-coding RNA and mRNA expression in different colored skin of koi carp.BMC genomics · 2019Article
- Differences in DNA Methylation Between Disease-Resistant and Disease-Susceptible Chinese Tongue Sole (Frontiers in genetics · 2019Article
- Morphological Characteristics and Comparative Transcriptome Analysis of Three Different Phenotypes ofFrontiers in genetics · 2019Article
- Identification and characterization of skin color microRNAs in Koi carp (Cyprinus carpio L.) by Illumina sequencing.BMC genomics · 2018Article
- Comparative Transcriptome and DNA methylation analyses of the molecular mechanisms underlying skin color variations in Crucian carp (Carassius carassius L.).BMC genetics · 2017Article
- Morphological Characters and Transcriptome Profiles Associated with Black Skin and Red Skin in Crimson Snapper (Lutjanus erythropterus).International journal of molecular sciences · 2015Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Teleosts have more types of chromatophores than other vertebrates and the genetic basis for pigmentation is highly conserved among vertebrates. Therefore, teleosts are important models to study the mechanism of pigmentation. Although functional genes and genetic variations of pigmentation have been studied, the mechanisms of different skin coloration remains poorly understood. The koi strain of common carp has various colors and patterns, making it a good model for studying the genetic basis of pigmentation. We performed RNA-sequencing for red skin and white skin and identified 62 differentially expressed genes (DEGs). Most of them were validated with RT-qPCR. The up-regulated DEGs in red skin were enriched in Kupffer's vesicle development while the up-regulated DEGs in white skin were involved in cytoskeletal protein binding, sarcomere organization and glycogen phosphorylase activity. The distinct enriched activity might be associated with different structures and functions in erythrophores and iridophores. The DNA methylation levels of two selected DEGs inversely correlated with gene expression, indicating the participation of DNA methylation in the coloration. This expression characterization of red-white skin along with the accompanying transcriptome-wide expression data will be a useful resource for further studies of pigment cell biology.
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