ReviewCurrent topics in behavioral neurosciences2016
Motivational Deficits in Schizophrenia and the Representation of Expected Value.
Review in Current topics in behavioral neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
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- Common Neural Deficits in Social and Monetary Reinforcement Learning in Schizophrenia.Schizophrenia bulletin · 2026Article
- Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis.Translational psychiatry · 2026Article
- Higher motivation and pleasure scores predict more reliance on model-free decision making.Cognitive, affective & behavioral neuroscience · 2025Article
- Placebo and nocebo phenomena in schizophrenia spectrum disorders: a narrative review on current knowledge and potential future directions.Psychological medicine · 2025Review
- Inhibition of striatal indirect pathway during second postnatal week leads to long-lasting deficits in motivated behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Probabalistic reinforcement learning impairments predict negative symptom severity and risk for conversion in youth at clinical high-risk for psychosis.Psychological medicine · 2025Article
- Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits.Biological psychiatry · 2024Article
- Electrophysiological Correlates of Reward Anticipation in Subjects with Schizophrenia: An ERP Microstate Study.Brain topography · 2024Article
- Altered Associations Between Motivated Performance and Frontostriatal Functional Connectivity During Reward Anticipation in Schizophrenia.Schizophrenia bulletin · 2023Article
- Effort-based decision making in schizotypy and its relationship with amotivation and psychosocial functioning.Frontiers in psychiatry · 2023Article
- Reduced learning bias towards the reward context in medication-naive first-episode schizophrenia patients.BMC psychiatry · 2022Article
- Confirmation Bias in the Course of Instructed Reinforcement Learning in Schizophrenia-Spectrum Disorders.Brain sciences · 2022Article
- Psychological Dimensions Relevant to Motivation and Pleasure in Schizophrenia.Frontiers in behavioral neuroscience · 2022Review
- Sex differences in schizophrenia: a longitudinal methylome analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Acute and Lifetime Stress and Psychotic Illness: The Roles of Reward and Salience Networks.Journal of psychiatry and brain science · 2022Article
- Range-Adaptive Value Representation in Different Stages of Schizophrenia: A Proof of Concept Study.Schizophrenia bulletin · 2021Article
- Altered risky decision making in patients with early non-affective psychosis.European archives of psychiatry and clinical neuroscience · 2021Article
- Increased face detection responses on the mooney faces test in people at clinical high risk for psychosis.NPJ schizophrenia · 2021Article
- Differential effects of d- and l-enantiomers of govadine on distinct forms of cognitive flexibility and a comparison with dopaminergic drugs.Psychopharmacology · 2021Article
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Abstract
Motivational deficits (avolition and anhedonia) have historically been considered important negative symptoms of schizophrenia (SZ). Numerous studies have attempted to identify the neural substrates of avolition and anhedonia in schizophrenia , but these studies have not produced much agreement. Deficits in various aspects of reinforcement processing have been observed in individuals with schizophrenia, but it is not exactly clear which of these deficits actually engender motivational impairments in SZ. The purpose of this chapter is to examine how various reinforcement-related behavioral and neural signals could contribute to motivational impairments in both schizophrenia and psychiatric illness, in general. In particular, we describe different aspects of the concept of expected value (EV), such as the distinction between the EV of stimuli and the expected value of actions, the acquisition of value versus the estimation of value, and the discounting of value as a consequence of time or effort required. We conclude that avolition and anhedonia in SZ are most commonly tied to aberrant signals for expected value, in the context of learning. We discuss implications for further research on the neural substrates of motivational impairments in psychiatric illness.
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