Evidence map›Paper›PMID 26370918›Full record

Trial reportJournal of clinical hypertension (Greenwich, Conn.)2016

Baseline Antihypertensive Drug Count and Patient Response to Hypertension Medication Management.

Matthew J Crowley, Maren K Olsen, Sandra L Woolson, Heather A King, Eugene Z Oddone, Hayden B Bosworth

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Matthew J CrowleyCenter for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC.
Maren K OlsenCenter for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC.
Sandra L WoolsonCenter for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC.
Heather A KingCenter for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC.
Eugene Z OddoneCenter for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC.
Hayden B BosworthCenter for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC.
Duke University · USDurham VA Medical Center · USDuke Medical Center · US

Funding

Intramural VA VA999999
6 · The paper itself

Abstract

Telemedicine-based medication management improves hypertension control, but has been evaluated primarily in patients with low antihypertensive drug counts. Its impact on patients taking three or more antihypertensive agents is not well-established. To address this evidence gap, the authors conducted an exploratory analysis of an 18-month, 591-patient trial of telemedicine-based hypertension medication management. Using general linear models, the effect of medication management on blood pressure for patients taking two or fewer antihypertensive agents at study baseline vs those taking three or more was compared. While patients taking two or fewer antihypertensive agents had a significant reduction in systolic blood pressure with medication management, those taking three or more had no such response. The between-subgroup effect difference was statistically significant at 6 months (-6.4 mm Hg [95% confidence interval, -12.2 to -0.6]) and near significant at 18 months (-6.0 mm Hg [95% confidence interval, -12.2 to 0.2]). These findings suggest that baseline antihypertensive drug count may impact how patients respond to hypertension medication management and emphasize the need to study management strategies specifically in patients taking three or more antihypertensive medications.

Indexed as

Disease ManagementAntihypertensive AgentsBlood PressureBlood Pressure DeterminationDrug Therapy, CombinationDrug UtilizationFollow-Up StudiesHumansHypertensionMaleMiddle AgedTelemedicineTime FactorsAntihypertensive Agents

Identifiers

PMID26370918
PMCPMC4792789
OpenAlexW2134227710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.