ArticleFukushima journal of medical science2015
OUTCOME OF CLIVAL CHORDOMAS AFTER SKULL BASE SURGERIES WITH MEAN FOLLOW-UP OF 10 YEARS.
Article in Fukushima journal of medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Proton beam therapy for skull base chordomas: a systematic review of tumor control rates and survival rates.Neurosurgical review · 2022Pooled it
- Endoscopic endonasal surgery for cholesteatomas of the posterior cranial fossa and parasellar region. A challenging pathology for experts.Neurosurgical review · 2026Article
- Metastatic skull base chordoma: A systematic review.Laryngoscope investigative otolaryngology · 2022Review
- Gamma Knife Stereotactic Radiosurgery for the treatment of chordomas and chondrosarcomas.Acta neurochirurgica · 2021Article
- Article
- Clival chordoma with drop metastases.Journal of radiology case reports · 2018Article
- Endoscopic endonasal transclival removal of tumors of the clivus and anterior region of the posterior cranial fossa (results of surgical treatment of 140 patients).Chinese neurosurgical journal · 2018Article
- Endoscopic Approach to Remove Intra-extracranial Tumors in Various Skull Base Regions: 10-year Experience of a Single Center.Chinese medical journal · 2017Article
- Multidisciplinary management of clival chordomas; long-term clinical outcome in a single-institution consecutive series.Acta neurochirurgica · 2017Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveSkull base chordomas are clinically malignant because of the difficulty of total removal, high recurrence rate, and occasional drop metastasis. Although aggressive surgical resection and postoperative radiation have been recommended, the long-term outcome remains unsatisfactory.
methodsFrom 1992 to 2011, we treated 24 patients with skull base chordoma using aggressive surgical removal as a principal strategy. Skull base approaches were selected according to tumor extension to remove the tumor and surrounding bone as completely as possible. After surgery, all patients were closely observed with MRI to find small and localized recurrent tumors, which were treated with gamma-knife radiosurgery or surgical resection. The mean postoperative follow-up duration was 10.2 years (range, 1-17.2 years).
resultsThe 5-, 10-, and 15-year overall survival rates were 86%, 72%, and 72%, respectively. The 5- and 10-year progression-free survival rates were 47% and 35%, respectively. Tumor extension to the brainstem and partial tumor removal were the factors related to poor survival.
conclusionsOur results suggest that aggressive surgical removal improves the long-term outcome of patients with skull base chordoma. We would like to emphasize that skull base chordomas should be aggressively removed using various skull base approaches.
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