Evidence map›Paper›PMID 26370671›Full record

ArticleJournal of endocrinological investigation2016

Gene expression of thyroid-specific transcription factors may help diagnose thyroid lesions but are not determinants of tumor progression.

F A Batista, L S Ward, M A Marcello, M B Martins, K C Peres, C Torricelli, N E Bufalo, F A Soares, M J da Silva, L V M Assumpção

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

F A BatistaLaboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), School of Medical Sciences, University of Campinas (Unicamp), Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas, São Paulo, 13083-887, Brazil. fernando815@gmail.com.
L S WardLaboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), School of Medical Sciences, University of Campinas (Unicamp), Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas, São Paulo, 13083-887, Brazil.
M A MarcelloLaboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), School of Medical Sciences, University of Campinas (Unicamp), Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas, São Paulo, 13083-887, Brazil.
M B MartinsLaboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), School of Medical Sciences, University of Campinas (Unicamp), Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas, São Paulo, 13083-887, Brazil.
K C PeresLaboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), School of Medical Sciences, University of Campinas (Unicamp), Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas, São Paulo, 13083-887, Brazil.
C TorricelliLaboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), School of Medical Sciences, University of Campinas (Unicamp), Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas, São Paulo, 13083-887, Brazil.
N E BufaloLaboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), School of Medical Sciences, University of Campinas (Unicamp), Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas, São Paulo, 13083-887, Brazil.
F A SoaresDepartment of Pathology, AC Camargo Hospital - Antonio Prudente Foundation, Rua Professor Antônio Prudente, 211, Liberdade, São Paulo, São Paulo, 01509-010, Brazil.
M J da SilvaMolecular Biology and Genetic Engineering Center (CBMEG), University of Campinas (Unicamp), Avenida Cândido Rondon, Cidade Universitaria Zeferino Vaz, Campinas, São Paulo, 13083-875, Brazil.
L V M AssumpçãoLaboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), School of Medical Sciences, University of Campinas (Unicamp), Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas, São Paulo, 13083-887, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRAC Camargo Hospital · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe role of thyroid-specific transcription factors in thyroid malignancy is still poorly understood, so we investigate thyroid-specific transcription factors gene expression both in benign and in malignant thyroid nodules, aiming to study a possible clinical utility of these molecules.

methodsWe quantified TTF-1, FOXE1 and PAX8 mRNA levels, relating their expression to diagnostic and prognostic features of thyroid tumors. RNA was extracted from 4 normal thyroid tissues, 101 malignant [99 papillary thyroid carcinomas (PTC) and 2 anaplastic thyroid carcinomas] and 99 benign thyroid lesion tissues [49 goiter and 50 follicular adenomas (FA)].

resultsLevels of mRNA of both FOXE1 (P < 0.0001) and PAX8 (P < 0.0001) genes, but not TTF-1 (P = 0.7056), were higher in benign than in malignant thyroid lesions. FOXE1 was able to identify malignant nodules with 75.8 % sensitivity, 76.1 % specificity, 75.8 % positive predictive value, 76.1 % negative predictive value and 75.9 % accuracy. PAX8 was able to identify malignancy with 60.6 % sensitivity, 81.1 % specificity, 76.9 % positive predictive value, 66.4 % negative predictive value and 70.6 % accuracy. Both FOXE1 and PAX8 gene expression patterns were also able to differentiate FA from the follicular variant of PTC-FVPTC. However, the investigated gene expression was neither associated with any clinical feature of tumor aggressiveness nor associated with recurrence or survival.

conclusionsWe suggest that FOXE1 and PAX8 gene expression patterns may help to diagnose thyroid nodules, identifying malignancy and characterizing follicular-patterned thyroid lesions, but are not determinants of thyroid tumor progression.

Indexed as

Adenocarcinoma, FollicularAdolescentAdultAgedBiomarkers, TumorCarcinoma, PapillaryCase-Control StudiesDNA-Binding ProteinsFemaleFollow-Up StudiesForkhead Transcription FactorsHumansMaleMiddle AgedNeoplasm StagingPAX8 Transcription FactorBiomarkers, TumorDNA-Binding ProteinsForkhead Transcription FactorsFOXE1 protein, humanPAX8 protein, humanPAX8 Transcription FactorRNA, MessengerTranscription FactorsTTF1 protein, humanDiagnosticFollicular thyroid lesionFOXE1PAX8Thyroid nodulesTTF-1

Identifiers

PMID26370671
OpenAlexW1632701116

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.