ArticleBMC evolutionary biology2015
Ancient gene duplications have shaped developmental stage-specific expression in Pristionchus pacificus.
Article in BMC evolutionary biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Evolution of sensory systems underlies the emergence of predatory feeding behaviors in nematodes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Paralog-specific miRNA regulation uncouples ASER gene repression from the canonicalmicroPublication biology · 2026Article
- Evolution of sensory systems underlies the emergence of predatory feeding behaviours in nematodes.bioRxiv : the preprint server for biology · 2025Article
- High Nutritional Conditions Influence Feeding Plasticity in Pristionchus pacificus and Render Worms Non-Predatory.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Long Noncoding RNAs in Response to Hyperosmolarity Stress, but Not Salt Stress, Were Mainly Enriched in the Rice Roots.International journal of molecular sciences · 2024Article
- Thousands of Pristionchus pacificus orphan genes were integrated into developmental networks that respond to diverse environmental microbiota.PLoS genetics · 2023Article
- Horizontally Acquired Cellulases Assist the Expansion of Dietary Range in Pristionchus Nematodes.Molecular biology and evolution · 2022Article
- Single worm transcriptomics identifies a developmental core network of oscillating genes with deep conservation across nematodes.Genome research · 2021Article
- Steroid hormone pathways coordinate developmental diapause and olfactory remodeling in Pristionchus pacificus.Genetics · 2021Article
- Different combinations of serotonin receptors regulate predatory and bacterial feeding behaviors in the nematode Pristionchus pacificus.G3 (Bethesda, Md.) · 2021Article
- Polyphenism of a Novel Trait Integrated Rapidly Evolving Genes into Ancestrally Plastic Networks.Molecular biology and evolution · 2021Article
- Spatial Transcriptomics of Nematodes Identifies Sperm Cells as a Source of Genomic Novelty and Rapid Evolution.Molecular biology and evolution · 2021Article
- Comparative genomics and community curation further improve gene annotations in the nematode Pristionchus pacificus.BMC genomics · 2020Article
- Comparative Transcriptomics across Nematode Life Cycles Reveal Gene Expression Conservation and Correlated Evolution in Adjacent Developmental Stages.Genome biology and evolution · 2020Article
- Crowdsourcing and the feasibility of manual gene annotation: A pilot study in the nematode Pristionchus pacificus.Scientific reports · 2019Article
- Article
- Two new Species ofJournal of nematology · 2019Article
- Article
- Deep taxon sampling reveals the evolutionary dynamics of novel gene families inGenome research · 2018Article
- Young genes have distinct gene structure, epigenetic profiles, and transcriptional regulation.Genome research · 2018Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe development of multicellular organisms is accompanied by gene expression changes in differentiating cells. Profiling stage-specific expression during development may reveal important insights into gene sets that contributed to the morphological diversity across the animal kingdom.
resultsWe sequenced RNA-seq libraries throughout a developmental timecourse of the nematode Pristionchus pacificus. The transcriptomes reflect early larval stages, adult worms including late larvae, and growth-arrested dauer larvae and allowed the identification of developmentally regulated gene clusters. Our data reveals similar trends as previous transcriptome profiling of dauer worms and represents the first expression data for early larvae in P. pacificus. Gene expression clusters characterizing early larval stages show most significant enrichments of chaperones, while collagens are most significantly enriched in transcriptomes of late larvae and adult worms. By combining expression data with phylogenetic analysis, we found that developmentally regulated genes are found in paralogous clusters that have arisen through lineage-specific duplications after the split from the Caenorhabditis elegans branch.
conclusionsWe propose that gene duplications of developmentally regulated genes represent a plausible evolutionary mechanism to increase the dosage of stage-specific expression. Consequently, this may contribute to the substantial divergence in expression profiles that has been observed across larger evolutionary time scales.
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