ArticleScientific reports2015
Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC2-signaling deficient mice.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Meta-Analysis Characterizing Stem-Like Gene Expression in the Suprachiasmatic Nucleus and Its Circadian Clock.BioMed research international · 2018Pooled it
- Differential effects of sex and age on daily and infradian rhythms of mice.The Journal of physiology · 2026Article
- Loss of neuropeptide signalling alters temporal expression of mouse suprachiasmatic neuronal state and excitability.The European journal of neuroscience · 2024Article
- An Arabidopsis Cell Culture With Weak Circadian Rhythms Under Constant Light Compared With Constant Dark Can Be Rescued by ELF3.Plant direct · 2024Article
- Reversible suppression of circadian-driven locomotor rhythms in mice using a gradual fragmentation of the day-night cycle.Scientific reports · 2023Article
- Article
- The VIP/VPAC1R Pathway Regulates Energy and Glucose Homeostasis by Modulating GLP-1, Glucagon, Leptin and PYY Levels in Mice.Biology · 2022Article
- Timed daily exercise remodels circadian rhythms in mice.Communications biology · 2021Article
- Genesis of the Master Circadian Pacemaker in Mice.Frontiers in neuroscience · 2021Review
- Reduced VIP Expression Affects Circadian Clock Function in VIP-IRES-CRE Mice (JAX 010908).Journal of biological rhythms · 2020Article
- Circuit development in the master clock network of mammals.The European journal of neuroscience · 2020Review
- The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock.International journal of molecular sciences · 2019Article
- A Symphony of Signals: Intercellular and Intracellular Signaling Mechanisms Underlying Circadian Timekeeping in Mice and Flies.International journal of molecular sciences · 2019Review
- Circadian Disruptions in the Myshkin Mouse Model of Mania Are Independent of Deficits in Suprachiasmatic Molecular Clock Function.Biological psychiatry · 2018Article
- Immunomodulatory Roles of PACAP and VIP: Lessons from Knockout Mice.Journal of molecular neuroscience : MN · 2018Review
- The choroid plexus is an important circadian clock component.Nature communications · 2018Article
- A Series of Suppressive Signals within the Drosophila Circadian Neural Circuit Generates Sequential Daily Outputs.Neuron · 2017Article
- PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice.PloS one · 2017Article
- In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms.Neuroscience · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Individual neurons in the suprachiasmatic nuclei (SCN) contain an intracellular molecular clock and use intercellular signaling to synchronize their timekeeping activities so that the SCN can coordinate brain physiology and behavior. The neuropeptide vasoactive intestinal polypeptide (VIP) and its VPAC2 receptor form a key component of intercellular signaling systems in the SCN and critically control cellular coupling. Targeted mutations in either the intracellular clock or intercellular neuropeptide signaling mechanisms, such as VIP-VPAC2 signaling, can lead to desynchronization of SCN neuronal clocks and loss of behavioral rhythms. An important goal in chronobiology is to develop interventions to correct deficiencies in circadian timekeeping. Here we show that extended exposure to constant light promotes synchrony among SCN clock cells and the expression of ~24 h rhythms in behavior in mice in which intercellular signaling is disrupted through loss of VIP-VPAC2 signaling. This study highlights the importance of SCN synchrony for the expression of rhythms in behavior and reveals how non-invasive manipulations in the external environment can be used to overcome neurochemical communication deficits in this important brain system.
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