Evidence map›Paper›PMID 26370447›Full record

ArticleJournal of the American Heart Association2015

Adequate Selection of a Therapeutic Site Enables Efficient Development of Collateral Vessels in Angiogenic Treatment With Bone Marrow Mononuclear Cells.

Masaru Nemoto, Hiroyuki Koyama, Ayako Nishiyama, Kunihiro Shigematsu, Tetsuro Miyata, Toshiaki Watanabe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Masaru NemotoDepartment of Vascular Surgery, Graduate School of Medicine, University of Tokyo, Japan (M.N., H.K., A.N., K.S., T.W.).
Hiroyuki KoyamaDepartment of Vascular Surgery, Graduate School of Medicine, University of Tokyo, Japan (M.N., H.K., A.N., K.S., T.W.) Translational Research Center, The University of Tokyo Hospital, Tokyo, Japan (H.K.) Department of Vascular Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan (H.K.).
Ayako NishiyamaDepartment of Vascular Surgery, Graduate School of Medicine, University of Tokyo, Japan (M.N., H.K., A.N., K.S., T.W.).
Kunihiro ShigematsuDepartment of Vascular Surgery, Graduate School of Medicine, University of Tokyo, Japan (M.N., H.K., A.N., K.S., T.W.).
Tetsuro MiyataVascular Center, Sanno Hospital and Sanno Medical Center, Tokyo, Japan (T.M.).
Toshiaki WatanabeDepartment of Vascular Surgery, Graduate School of Medicine, University of Tokyo, Japan (M.N., H.K., A.N., K.S., T.W.).
The University of Tokyo · JPSanno Medical Center · JPUniversity of Tokyo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInduction of angiogenic mechanisms to promote development of collateral vessels is considered promising for the treatment of peripheral arterial diseases. Collateral vessels generally develop from preexisting arteriolar connections, bypassing the diseased artery. We speculated that induction of angiogenic mechanisms should be directed to such arteriolar connections to achieve efficient collateral development. The aim of this study was to verify this hypothesis using autologous transplantation of bone marrow mononuclear cells in the rabbit model of chronic limb ischemia. METHODS AND

resultsThe left femoral artery was excised to induce limb ischemia in male rabbits. In this model, arteriolar connections in the left coccygeofemoral muscle tend to develop into collateral vessels, although this transformation is insufficient to alleviate the limb ischemia. In contrast, arteriolar connections in the closely located adductor muscle do not readily develop into collateral vessels. At 21 days after ischemia initiation, a sufficient number of automononuclear cells were selectively injected in the left coccygeofemoral muscle (coccygeo group) or left adductor muscle (adductor group). Evaluation of calf blood pressure ratios, blood flow in the left internal iliac artery, and angiographic scores at day 28 after injection revealed that collateral development and improvement of limb ischemia were significantly more efficient in the coccygeo group than in the adductor group. Morphometric analysis of the coccygeofemoral muscle at day 14 showed similar results.

conclusionsSpecific delivery of mononuclear cells to the coccygeofemoral but not the adductor muscle effectively improves collateral circulation in the rabbit model of limb ischemia and suggests that adequate site selection can facilitate therapeutic angiogenesis.

Indexed as

Bone Marrow TransplantationCollateral CirculationNeovascularization, PhysiologicAnimalsChronic DiseaseDisease Models, AnimalFemoral ArteryHindlimbIliac ArteryIschemiaKi-67 AntigenMaleMuscle, SkeletalRabbitsRadiographyReceptor, Fibroblast Growth Factor, Type 1Ki-67 AntigenReceptor, Fibroblast Growth Factor, Type 1Vascular Endothelial Growth Factor Aarteriogenesiscollateral circulationischemia

Identifiers

PMID26370447
PMCPMC4599510
OpenAlexW2099836117

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.