Evidence map›Paper›PMID 26370422›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2016

Concurrent chemo-radiotherapy in elderly patients: tolerance and compliance in a series of 137 patients.

M Di Genesio Pagliuca, C Perotti, G Apicella, A Galla, M Guffi, M Paolini, L Donis, V Amisano, S Torrente, I Manfredda and 1 more

Abstract read
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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Factors predicting intolerance to definitive conventional radiotherapy in geriatric patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

M Di Genesio PagliucaChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy.
C PerottiChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy.
G ApicellaChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy.
A GallaChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy.
M GuffiChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy.
M PaoliniChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy.
L DonisChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy.
V AmisanoChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy.
S TorrenteChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy.
I ManfreddaChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy.
M KrengliChair of Radiotherapy, Division of Radiotherapy, Department of Translational Medicine, University Hospital "Maggiore della Carità", University of "Piemonte Orientale", Via Solaroli, 17, 28100, Novara, Italy. krengli@med.unipmn.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAggressive cancer treatment is a challenge in elderly patients. The present study aims to assess tolerance in terms of acute toxicity and compliance of concurrent chemo-radiotherapy (cCRT) in a series of patients aged ≥70 years. MATERIALS AND

methodsClinical records of patients aged ≥70 years who underwent cCRT between January 2005 and December 2013 were reviewed. Concurrent CRT had curative intent in 134 patients (97.8 %) and palliative intent in 3 patients (2.2 %). Chemotherapy (CT) drugs and schedule were selected according to tumor histology. Radiotherapy median dose was 45.0 Gy (range 11-70 Gy) for curative purposes and 54 Gy (range 40-56 Gy) for palliative purposes. Incidence of acute toxicity and compliance to cCRT were analyzed and correlated with age, Karnofsky Performance Status (KPS), and Charlson Comorbidity Index (CCI).

resultsOverall, 137 patients, 82 males (60 %) and 55 females (40 %), median age 74 years (range 70-90 years) were analyzed. Concurrent CRT schedule was completed by 132 patients (96.4 %). Thirty-one of these patients (23.5 %) temporarily interrupted treatment. Hematological toxicity with grade ≥1 was observed in 25 patients (18.2 %), gastrointestinal toxicity in 55 (40.1 %), and genitourinary in 13 (9.5 %). Mucositis with grade ≥1 was recorded in 19 patients (13.9 %). No statistical significant correlation between KPS, CCI, and toxicity was found. A correlation trend between mucositis and patient age (p = 0.05) was observed.

conclusionConcurrent CRT for elderly was feasible and quite well tolerated. Great attention in prescribing CT dose should be paid to limit acute toxicity.

Indexed as

AgedAged, 80 and overChemoradiotherapyFemaleHumansMaleNeoplasmsPatient ComplianceRetrospective StudiesChemo-radiotherapyComplianceElderlyToxicity

Identifiers

PMID26370422

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.