ArticleScientific reports2015
Imbalance between the expression dosages of X-chromosome and autosomal genes in mammalian oocytes.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Searching for the 'X' factor: investigating the genetics of primary ovarian insufficiency.Journal of ovarian research · 2024Review
- Dynamic Spatial-temporal Expression Ratio of X Chromosome to Autosomes but Stable Dosage Compensation in Mammals.Genomics, proteomics & bioinformatics · 2023Article
- Elastic dosage compensation by X-chromosome upregulation.Nature communications · 2022Article
- De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells.Stem cell reports · 2021Article
- Concurrent X chromosome inactivation and upregulation during non-human primate preimplantation development revealed by single-cell RNA-sequencing.Scientific reports · 2021Article
- Effects of the Sex Chromosome Complement, XX, XO, or XY, on the Transcriptome and Development of Mouse Oocytes During Follicular Growth.Frontiers in genetics · 2021Article
- Dosage Compensation of the X Chromosomes in Bovine Germline, Early Embryos, and Somatic Tissues.Genome biology and evolution · 2019Article
- Dosage compensation in the process of inactivation/reactivation during both germ cell development and early embryogenesis in mouse.Scientific reports · 2017Article
- Non-Canonical and Sexually Dimorphic X Dosage Compensation States in the Mouse and Human Germline.Developmental cell · 2017Article
- Spatiotemporal dynamics of OCT4 protein localization during preimplantation development in mice.Reproduction (Cambridge, England) · 2016Article
- Dosage compensation of the sex chromosomes and autosomes.Seminars in cell & developmental biology · 2016Review
- Chromatin condensation of Xist genomic loci during oogenesis in mice.Development (Cambridge, England) · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oocytes have unique characteristics compared with other cell types. In mouse and human oocytes, two X chromosomes are maintained in the active state. Previous microarray studies have shown that the balance of the expression state is maintained in haploid oocytes. Here, we investigated transcripts using RNA-sequence technology in mouse and human oocytes. The median expression ratio between X chromosome and autosomal genes (X:A) in immature mouse oocytes increased as the gene expression levels increased, reaching a value of 1. However, the ratio in mature oocytes was under 1 for all expression categories. Moreover, we observed a markedly low ratio resulting from the bimodal expression patterns of X-linked genes. The low X:A expression ratio in mature oocyte was independent of DNA methylation. While mature human oocytes exhibited a slightly low X:A expression ratio, this was the result of the skewed high frequency of lowly expressed X-linked genes rather than the bimodal state. We propose that this imbalance between the expression dosages of X-chromosome and autosomal genes is a feature of transcripts in mammalian oocytes lacking X-chromosome inactivation.
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