ArticleMalaria journal2015
Rise of multiple insecticide resistance in Anopheles funestus in Malawi: a major concern for malaria vector control.
Article in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
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Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Piperonyl butoxide (PBO) combined with pyrethroids in insecticide-treated nets to prevent malaria in Africa.The Cochrane database of systematic reviews · 2021Pooled it
- Piperonyl butoxide (PBO) combined with pyrethroids in insecticide-treated nets to prevent malaria in Africa.The Cochrane database of systematic reviews · 2018Pooled it
- Assessment of the effect of larval source management and house improvement on malaria transmission when added to standard malaria control strategies in southern Malawi: study protocol for a cluster-randomised controlled trial.BMC infectious diseases · 2017Trial
- Modelling the impact of adopting new-generation insecticide-treated nets on malaria transmission and insecticide resistance.Parasites & vectors · 2026Article
- Integrating routinely collected mosquito vector and human behavioral data for malaria prevention: A case example in central region Malawi.Malaria journal · 2026Article
- Transcriptomic signatures of high‑intensity pyrethroid resistance in Anopheles gambiae from a Cameroonian agricultural hotspot.BMC genomics · 2026Article
- Four-year monitoring of the malaria vector Anopheles funestus in central-west Cameroon reveals an escalation of pyrethroid resistance combined with high malaria transmission.BMC infectious diseases · 2026Article
- Spatial Heterogeneity ofJournal of parasitology research · 2026Review
- Genomic Drivers of Pyrethroid Resistance Escalation in the Malaria Vector Anopheles funestus Across Africa.Molecular biology and evolution · 2025Article
- Characterizing the escalation of pyrethroid resistance and its impact on bed nets efficacy alongside molecular basis in Anopheles funestus from Cameroon.Malaria journal · 2025Article
- Metabolic resistance to pyrethroids with possible involvement of non-coding ribonucleic acids in Anopheles funestus, the major malaria vector in western Kenya.BMC genomics · 2025Article
- Article
- Temporal evolution of insecticide resistance and bionomics in Anopheles funestus, a key malaria vector in Uganda.Scientific reports · 2024Article
- Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b genes drive pyrethroid resistance in Anopheles funestus in West Africa.BMC biology · 2024Article
- Tiny Green Army: Fighting Malaria with Plants and Nanotechnology.Pharmaceutics · 2024Review
- Article
- Non-Coding RNAs Potentially Involved in Pyrethroid Resistance of Anopheles funestus Population in Western Kenya.Research square · 2024Article
- Detection of insecticide resistance markers in Anopheles funestus from the Democratic Republic of the Congo using a targeted amplicon sequencing panel.Scientific reports · 2023Article
- Evidence of intensification of pyrethroid resistance in the major malaria vectors in Kinshasa, Democratic Republic of Congo.Scientific reports · 2023Article
- Barriers to accessing malaria treatment amongst school-age children in rural Malawi.Malaria journal · 2023Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundDeciphering the dynamics and evolution of insecticide resistance in malaria vectors is crucial for successful vector control. This study reports an increase of resistance intensity and a rise of multiple insecticide resistance in Anopheles funestus in Malawi leading to reduced bed net efficacy.
methodsAnopheles funestus group mosquitoes were collected in southern Malawi and the species composition, Plasmodium infection rate, susceptibility to insecticides and molecular bases of the resistance were analysed.
resultsMosquito collection revealed a predominance of An. funestus group mosquitoes with a high hybrid rate (12.2 %) suggesting extensive species hybridization. An. funestus sensu stricto was the main Plasmodium vector (4.8 % infection). Consistently high levels of resistance to pyrethroid and carbamate insecticides were recorded and had increased between 2009 and 2014. Furthermore, the 2014 collection exhibited multiple insecticide resistance, notably to DDT, contrary to 2009. Increased pyrethroid resistance correlates with reduced efficacy of bed nets (<5 % mortality by Olyset(®) net), which can compromise control efforts. This change in resistance dynamics is mirrored by prevalent resistance mechanisms, firstly with increased over-expression of key pyrethroid resistance genes (CYP6Pa/b and CYP6M7) in 2014 and secondly, detection of the A296S-RDL dieldrin resistance mutation for the first time. However, the L119F-GSTe2 and kdr mutations were absent.
conclusionsSuch increased resistance levels and rise of multiple resistance highlight the need to rapidly implement resistance management strategies to preserve the effectiveness of existing insecticide-based control interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.