ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Consequences of Adolescent Ethanol Consumption on Risk Preference and Orbitofrontal Cortex Encoding of Reward.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration.Drug and alcohol dependence · 2020Trial
- Assessing orbitofrontal cortex volume as a predictor of subjective response to alcohol during early adolescence.Alcohol (Fayetteville, N.Y.) · 2025Article
- Individual and sex differences in frontloading behavior and approach- avoidance conflict preference predict addiction-like ethanol seeking in rats.Scientific reports · 2025Article
- Adolescent alcohol exposure persistently alters orbitofrontal cortical encoding of Pavlovian conditional stimulus components in female rats.Scientific reports · 2024Article
- Sex-specific decision-making impairments and striatal dopaminergic changes after binge drinking history in rats.Frontiers in pharmacology · 2023Article
- Propensity for risky choices despite lower cue reactivity in adolescent rats.Frontiers in behavioral neuroscience · 2023Article
- Residence in High-Crime Neighborhoods Moderates the Association Between Interleukin 6 and Social and Nonsocial Reward Brain Responses.Biological psychiatry global open science · 2022Article
- Orbitofrontal cortex subregion inhibition during binge-like and aversion-resistant alcohol drinking.Alcohol (Fayetteville, N.Y.) · 2022Article
- Short-term Montreal Cognitive Assessment predicts functional outcome after endovascular therapy.Frontiers in aging neuroscience · 2022Article
- Impaired cognitive flexibility and heightened urgency are associated with increased alcohol consumption in rodent models of excessive drinking.Addiction biology · 2021Article
- Advances in understanding meso-cortico-limbic-striatal systems mediating risky reward seeking.Journal of neurochemistry · 2021Review
- Goal-striving tendencies moderate the relationship between reward-related brain function and peripheral inflammation.Brain, behavior, and immunity · 2021Article
- Review of Orbitofrontal Cortex in Alcohol Dependence: A Disrupted Cognitive Map?Alcoholism, clinical and experimental research · 2020Review
- Aberrations in Incentive Learning and Responding to Heroin in Male Rats After Adolescent or Adult Chronic Binge-Like Alcohol Exposure.Alcoholism, clinical and experimental research · 2020Article
- Selective impact of lateral orbitofrontal cortex inactivation on reinstatement of alcohol seeking in male Long-Evans rats.Neuropharmacology · 2020Article
- Persistent Alterations of Accumbal Cholinergic Interneurons and Cognitive Dysfunction after Adolescent Intermittent Ethanol Exposure.Neuroscience · 2019Article
- Effects of chronic cannabinoid exposure during adolescence on reward preference and mPFC activation in adulthood.Physiology & behavior · 2019Article
- Age of alcohol use initiation and psychiatric symptoms among young adult trauma survivors.Addictive behaviors · 2019Article
- The role of the orbitofrontal cortex in alcohol use, abuse, and dependence.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Alcohol Consumption during Adolescence in a Mouse Model of Binge Drinking Alters the Intrinsic Excitability and Function of the Prefrontal Cortex through a Reduction in the Hyperpolarization-Activated Cation Current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Critical development of the prefrontal cortex occurs during adolescence, a period of increased independence marked by decision making that often includes engagement in risky behaviors, such as substance use. Consumption of alcohol during adolescence has been associated with increased impulsivity that persists across the lifespan, an effect which may be caused by long-term disruptions in cortical processing of rewards. To determine if alcohol consumption alters cortical encoding of rewards of different sizes and probabilities, we gave rats limited access to alcohol in gelatin during adolescence only. In adulthood, we recorded the electrophysiological activity of individual neurons of the orbitofrontal cortex while rats performed a risk task that varied the level of risk from day-to-day. Rats that had consumed higher levels of alcohol showed increased risk preference in the task compared with control and low alcohol-consuming rats. Patterns of neuronal responses were identified using principal component analysis. Of the multiple patterns observed, only one was modulated by adolescent alcohol consumption and showed strongest modulation after reward receipt. This subpopulation of neurons showed blunted firing rates following rewards in alcohol-consuming rats, suggesting a mechanism through which adolescent alcohol exposure may have lasting effects on reward processing in the context of decision making. The differences in OFC responses between high alcohol consumers and control animals not given access to alcohol support the idea that, regardless of potential variability in innate alcohol preferences, voluntary consumption of alcohol during adolescence biases choice patterns longitudinally through alterations in cortical function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.