ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2015
Long-term follow-up for incident cirrhosis among pediatric cancer survivors with hepatitis C virus infection.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 15 citations in OpenAlex.
- Non-invasive assessment of hepatic fibrosis in pediatric survivors of acute lymphoblastic leukemia: a cross-sectional study.European journal of pediatrics · 2026Article
- Thyroid disturbances in children treated with combined pegylated interferon-alpha and ribavirin for chronic hepatitis C.Clinical and experimental pediatrics · 2020Article
- Chronic hepatitis C virus infection and neurocognitive function in adult survivors of childhood cancer.Cancer · 2017Article
- Hepatitis C virus infection in children and adolescents.Hepatology communications · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPediatric cancer patients who received blood transfusions were potentially exposed to hepatitis C virus (HCV) prior to second-generation HCV screening of blood products in 1992. Limited evidence is available about long-term incident cirrhosis in this population.
objectivesWe aimed to estimate the overall and sex-specific incidence of cirrhosis among HCV-seropositive survivors of pediatric cancer. STUDY
designWe identified 113HCV-seropositive pediatric cancer patients treated at St. Jude Children's Research Hospital between 1962 and 1997, who survived ≥5 years post-diagnosis, and were followed through 2014. Our outcome was cirrhosis determined by liver biopsy or diagnostic imaging. We used a competing-risk framework to estimate the overall and sex-specific cumulative incidence and 95% confidence limits (CL) of cirrhosis at 10-year follow-up intervals.
resultsThe median duration of follow-up was 30 years (interquartile range=28-36) post-cancer diagnosis. Cumulative incidence of cirrhosis increased at each 10-year interval from 0% after 10 years to 13% after 40 years (Ptrend<0.001). The median age at diagnosis of cirrhosis was 30 years (interquartile range=24-38). We observed a linear trend in incidence for males (Ptrend<0.001), with a cumulative incidence of 18% (95% CL: 6.1%, 34%) after 40 years. The cumulative incidence for females was 6.5% (95% CL: 0.42%, 26%) after 40 years, but we did not observe a linear trend (Ptrend=0.99).
conclusionOur results suggest that the incidence of cirrhosis is similar between HCV-seropositive pediatric cancer survivors and the general population given similar duration of follow-up, but survivors may be diagnosed with cirrhosis at an earlier age.
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