ArticleMolecular psychiatry2016
From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 112 citations in OpenAlex.
- The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors.CNS neuroscience & therapeutics · 2026Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Traumatic stress recruits an excitatory orbitofrontal-amygdala pathway to drive maladaptive aggression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Anterior Insula Activity during Alcohol and Social Reward Self-Administration and Choice in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
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- Transdiagnostic neuromodulation of impulsivity: current status and future trajectories.Translational psychiatry · 2025Review
- Sex and Genetic Differences in Behavioral Engagement of Crossed High Alcohol-Preferring and Low Alcohol-Preferring Mice.Genes, brain, and behavior · 2025Article
- Kleptomania on the impulsive-compulsive spectrum. Clinical and therapeutic considerations for women.Scientific reports · 2025Article
- From compulsivity to compulsion: the neural basis of compulsive disorders.Nature reviews. Neuroscience · 2024Review
- Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks.Translational psychiatry · 2024Article
- Neurobehavioral Precursors of Compulsive Cocaine Seeking in Dual Frontostriatal Circuits.Biological psychiatry global open science · 2024Article
- Characterization in the rat of the individual tendency to rely on alcohol to cope with distress and the ensuing vulnerability to drink compulsively.Brain communications · 2024Article
- Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats.Behavioral and brain functions : BBF · 2023Article
- The development of compulsive coping behavior depends on dorsolateral striatum dopamine-dependent mechanisms.Molecular psychiatry · 2023Article
- Associations between nesting, stereotypy, and working memory in deer mice: response to levetiracetam.Pharmacological reports : PR · 2023Article
- The development of compulsive coping behaviour is associated with a downregulation of Arc in a Locus Coeruleus neuronal ensemble.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- The relationship between moral judgment ability, parenting style, and perfectionism in obsessive-compulsive disorder patients: A mediating analysis.Frontiers in psychology · 2023Article
- Modeling Suicidality with Multimodal Impulsivity Characterization in Participants with Mental Health Disorder.Behavioural neurology · 2023Article
- Early-onset smoking theory of compulsivity development: a neurocognitive model for the development of compulsive tobacco smoking.Frontiers in psychiatry · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
Impulsivity is an endophenotype of vulnerability for compulsive behaviors. However, the neural mechanisms whereby impulsivity facilitates the development of compulsive disorders, such as addiction or obsessive compulsive disorder, remain unknown. We first investigated, in rats, anatomical and functional correlates of impulsivity in the anterior insular (AI) cortex by measuring both the thickness of, and cellular plasticity markers in, the AI with magnetic resonance imaging and in situ hybridization of the immediate early gene zif268, respectively. We then investigated the influence of bilateral AI cortex lesions on the high impulsivity trait, as measured in the five-choice serial reaction time task (5-CSRTT), and the associated propensity to develop compulsivity as measured by high drinking levels in a schedule-induced polydipsia procedure (SIP). We demonstrate that the AI cortex causally contributes to individual vulnerability to impulsive-compulsive behavior in rats. Motor impulsivity, as measured by premature responses in the 5-CSRTT, was shown to correlate with the thinness of the anterior region of the insular cortex, in which highly impulsive (HI) rats expressed lower zif268 mRNA levels. Lesions of AI reduced impulsive behavior in HI rats, which were also highly susceptible to develop compulsive behavior as measured in a SIP procedure. AI lesions also attenuated both the development and the expression of SIP. This study thus identifies the AI as a novel neural substrate of maladaptive impulse control mechanisms that may facilitate the development of compulsive disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.