ArticleGenetics, selection, evolution : GSE2015
Increased genetic gains in sheep, beef and dairy breeding programs from using female reproductive technologies combined with optimal contribution selection and genomic breeding values.
Article in Genetics, selection, evolution : GSE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- Establishment and validation of porcine embryo genomic selection system through SCNT technique.Journal of animal science and biotechnology · 2026Article
- The current status of artificial reproductive technologies in sheep.The Journal of reproduction and development · 2026Review
- The Establishment of a Sheep Embryo Genomic Selection System.International journal of molecular sciences · 2025Article
- Characterization of bacterial communities of ewe's vaginal tract and its potential impact on reproductive efficiency.Animal microbiome · 2025Article
- Application of Genomic Selection in Beef Cattle Disease Prevention.Animals : an open access journal from MDPI · 2025Review
- OptimizingAnimal reproduction · 2025Article
- Caprine and Ovine Genomic Selection-Progress and Application.Animals : an open access journal from MDPI · 2024Review
- Social effects on behaviorally-scored and pedometer-detected estrus in beef cattle.The Journal of reproduction and development · 2024Article
- Oocyte Competence of Prepubertal Sheep and Goat Oocytes: An Assessment of Large-Scale Chromatin Configuration and Epidermal Growth Factor Receptor Expression in Oocytes and Cumulus Cells.International journal of molecular sciences · 2024Article
- Exploring Endogenous and Exogenous Factors for Successful Artificial Insemination in Sheep: A Global Overview.Veterinary sciences · 2024Review
- Sperm selection by the oviduct: perspectives for male fertility and assisted reproductive technologies†.Biology of reproduction · 2023Article
- Impact of oestrus synchronization devices on ewes vaginal microbiota and artificial insemination outcome.Frontiers in microbiology · 2023Article
- Breeding Strategies to Optimize Effective Population Size in Low Census Captive Populations: The Case ofAnimals : an open access journal from MDPI · 2021Article
- Effect of adding growth factors duringVeterinary world · 2021Article
- Article
- Discovering lethal alleles across the turkey genome using a transmission ratio distortion approach.Animal genetics · 2020Article
- Intensified Use of Reproductive Technologies and Reduced Dimensions of Breeding Schemes Put Genetic Diversity at Risk in Dairy Cattle Breeds.Animals : an open access journal from MDPI · 2020Article
- Influence of the Ovine Genital Tract Microbiota on the Species Artificial Insemination Outcome. A Pilot Study in Commercial Sheep Farms.High-throughput · 2020Article
- Intraovarian injection of mesenchymal stem cells improves oocyte yield and in vitro embryo production in a bovine model of fertility loss.Scientific reports · 2020Article
- Towards Improving the Outcomes of Assisted Reproductive Technologies of Cattle and Sheep, with Particular Focus on Recipient Management.Animals : an open access journal from MDPI · 2020Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFemale reproductive technologies such as multiple ovulation and embryo transfer (MOET) and juvenile in vitro embryo production and embryo transfer (JIVET) can boost rates of genetic gain but they can also increase rates of inbreeding. Inbreeding can be managed using the principles of optimal contribution selection (OCS), which maximizes genetic gain while placing a penalty on the rate of inbreeding. We evaluated the potential benefits and synergies that exist between genomic selection (GS) and reproductive technologies under OCS for sheep and cattle breeding programs.
methodsVarious breeding program scenarios were simulated stochastically including: (1) a sheep breeding program for the selection of a single trait that could be measured either early or late in life; (2) a beef breeding program with an early or late trait; and (3) a dairy breeding program with a sex limited trait. OCS was applied using a range of penalties (severe to no penalty) on co-ancestry of selection candidates, with the possibility of using multiple ovulation and embryo transfer (MOET) and/or juvenile in vitro embryo production and embryo transfer (JIVET) for females. Each breeding program was simulated with and without genomic selection.
resultsAll breeding programs could be penalized to result in an inbreeding rate of 1 % increase per generation. The addition of MOET to artificial insemination or natural breeding (AI/N), without the use of GS yielded an extra 25 to 60 % genetic gain. The further addition of JIVET did not yield an extra genetic gain. When GS was used, MOET and MOET + JIVET programs increased rates of genetic gain by 38 to 76 % and 51 to 81 % compared to AI/N, respectively.
conclusionsLarge increases in genetic gain were found across species when female reproductive technologies combined with genomic selection were applied and inbreeding was managed, especially for breeding programs that focus on the selection of traits measured late in life or that are sex-limited. Optimal contribution selection was an effective tool to optimally allocate different combinations of reproductive technologies. Applying a range of penalties to co-ancestry of selection candidates allows a comprehensive exploration of the inbreeding vs. genetic gain space.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.