ArticleScientific reports2015
Transcriptomic variation of hepatopancreas reveals the energy metabolism and biological processes associated with molting in Chinese mitten crab, Eriocheir sinensis.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 131 citations in OpenAlex.
- Tissue and Sex-Specific Transcriptomic Signatures Underlying Aggression behavior of Chinese Mitten Crab (Eriocheir sinensis).Marine biotechnology (New York, N.Y.) · 2026Article
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- Integrated Analysis of ATAC-Seq and RNA-Seq Reveals the Signal Transduction Regulation of the Molting Cycle in the Muscle of Chinese Mitten Crab (Biomolecules · 2026Article
- Effects of Dietary Calcium and Magnesium Levels on the Growth Performance, Tissue Mineral Deposition, Exoskeleton Development, and Molting Performance of Chinese Mitten Crab (Aquaculture nutrition · 2026Article
- Impacts of Endogenous Factors and Ontogenetic Stages on the Metabolic Rate of the Mediterranean Spider CrabIntegrative organismal biology (Oxford, England) · 2025Article
- Genome-wide association and transcriptomic analysis and the identification of growth-related genes in Macrobrachium nipponense.BMC genomics · 2024Article
- The Role of Dietary Fatty Acids in Modulating Blue Crab (Animals : an open access journal from MDPI · 2024Article
- Hepatopancreas Transcriptome Analysis ofGenes · 2024Article
- NinaB and BCO Collaboratively Participate in the β-Carotene Catabolism in Crustaceans: A Case Study on Chinese Mitten CrabInternational journal of molecular sciences · 2024Article
- HAntioxidants (Basel, Switzerland) · 2024Article
- Morphological and Molecular Changes during Limb Regeneration of theAnimals : an open access journal from MDPI · 2024Article
- Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old Precocious Mechanism in the Chinese Mitten Crab,International journal of molecular sciences · 2023Article
- Evaluation of the Feasibility of Harvest Optimisation of Soft-Shell Mud Crab (Foods (Basel, Switzerland) · 2023Article
- Metabolomic and transcriptomic profiling reveals the effect of dietary protein and lipid levels on growth performance in loach (Frontiers in immunology · 2023Article
- Cottonseed Meal Protein Hydrolysate Improves the Growth Performance of Chinese Mitten Crab (Aquaculture nutrition · 2023Article
- "Omics" data unveil early molecular response underlying limb regeneration in the Chinese mitten crab,Science advances · 2022Article
- Hepatopancreas transcriptome analyses provide new insights into the molecular regulatory mechanism of fast ovary maturation in Macrobrachium nipponense.BMC genomics · 2022Article
- Comparative Transcriptome Analysis on the Regulatory Mechanism of Thoracic Ganglia inLife (Basel, Switzerland) · 2022Article
- Whole-body transcriptome analysis provides insights into the cascade of sequential expression events involved in growth, immunity, and metabolism during the molting cycle in Scylla paramamosain.Scientific reports · 2022Article
- Preference for Shelters at Different Developmental Stages of Chinese Mitten Crab (Animals : an open access journal from MDPI · 2022Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
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Abstract
Molting is a critical developmental process for crustaceans, yet the underlying molecular mechanism is unknown. In this study, we used RNA-Seq to investigate transcriptomic profiles of the hepatopancreas and identified differentially expressed genes at four molting stages of Chinese mitten crab (Eriocheir sinensis). A total of 97,398 transcripts were assembled, with 31,900 transcripts annotated. Transcriptomic comparison revealed 1,189 genes differentially expressed amongst different molting stages. We observed a pattern associated with energy metabolism and physiological responses during a molting cycle. In specific, differentially expressed genes enriched in postmolt were linked to energy consumption whereas genes enriched in intermolt were related to carbohydrates, lipids metabolic and biosynthetic processes. In premolt, a preparation stage for upcoming molting and energy consumption, highly expressed genes were enriched in response to steroid hormone stimulus and immune system development. The expression profiles of twelve functional genes detected via RNA-Seq were corroborated through real-time RT-PCR assay. Together, our results, including assembled transcriptomes, annotated functional elements and enriched differentially expressed genes amongst different molting stages, provide novel insights into the functions of the hepatopancreas in energy metabolism and biological processes pertaining to molting in crustaceans.
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