ArticleCritical care (London, England)2015
Daily estimation of the severity of organ dysfunctions in critically ill children by using the PELOD-2 score.
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Prognostic accuracy of SOFA and qSOFA for mortality among children with infection: a meta-analysis.Pediatric research · 2023Pooled it
- Scoring Systems for Organ Dysfunction and Multiple Organ Dysfunction: The PODIUM Consensus Conference.Pediatrics · 2022Pooled it
- Meta-Analysis for the Prediction of Mortality Rates in a Pediatric Intensive Care Unit Using Different Scores: PRISM-III/IV, PIM-3, and PELOD-2.Frontiers in pediatrics · 2021Pooled it
- Therapeutic effects and outcomes of rescue high-frequency oscillatory ventilation for premature infants with severe refractory respiratory failure.Scientific reports · 2021Trial
- Time from acute kidney injury to continuous renal replacement therapy and outcomes in critically ill children.Clinical kidney journal · 2026Article
- Intradialytic hypotension and hemodynamic phenotypes in children following continuous renal replacement therapy initiation.Pediatric research · 2026Observational
- Comparison of Phoenix Sepsis Score and traditional scoring systems in predicting mortality in PICU patients with suspected infection.Scientific reports · 2026Article
- Clinical characteristics and outcomes of pediatric cancer patients admitted to the intensive care unit during treatment: a retrospective analysis.Oncology reviews · 2026Article
- pSOFA score serves as predicting the severity and outcome of sepsis in critically ill children.Scientific reports · 2025Article
- Differential protein expression and enriched pathways in pediatric sepsis: identification of novel brain-associated biomarkers revealed through proteomic profiling.Molecular medicine (Cambridge, Mass.) · 2025Article
- Assessment of Phoenix sepsis score: characterization of a cohort of children of different primary statuses and ages, 2020-2024.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Advanced hemodynamic monitoring: feasibility of leveraging non-invasive electrocardiometry in critically ill pediatric patients requiring continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Massive Bleeding in Children With Cancer or Hematopoietic Cell Transplant: International, Multicenter Retrospective Study, 2017-2021.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Observational
- Patient follow-up after discharge from the paediatric intensive care unit: A scoping review.Nursing in critical care · 2025Article
- Trajectory and Risk Factors of Persistent Decline in Health-Related Quality of Life after Septic Shock in Children with Preexisting Neurologic Disability.Journal of pediatric intensive care · 2024Article
- Patterns of Multiple Organ Dysfunction and Renal Recovery in Critically Ill Children and Young Adults Receiving Continuous Renal Replacement Therapy.Critical care explorations · 2024Article
- Association of delayed adequate antimicrobial treatment and organ dysfunction in pediatric bloodstream infections.Pediatric research · 2024Article
- Comparison of Three Different Multiple Organ Dysfunction Scores for Predicting Mortality after Neonatal Cardiac Surgery.Children (Basel, Switzerland) · 2023Article
- Perioperative Nutritional Status and Organ Dysfunction Following Surgery for Congenital Heart Disease.Pediatric cardiology · 2023Article
- Modified NEOMOD score as a neonatal mortality prediction tool in a medium-income country: A validation diagnostic test study.Health science reports · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDaily or serial evaluation of multiple organ dysfunction syndrome (MODS) scores may provide useful information. We aimed to validate the daily (d) PELOD-2 score using the set of seven days proposed with the previous version of the score.
methodsIn all consecutive patients admitted to nine pediatric intensive care units (PICUs) we prospectively measured the dPELOD-2 score at day 1, 2, 5, 8, 12, 16, and 18. PICU mortality was used as the outcome dependent variable. The discriminant power of the dPELOD-2 scores was estimated using the area under the ROC curve and the calibration using the Hosmer-Lemeshow chi-square test. We used a logistic regression to investigate the relationship between the dPELOD-2 scores and outcome, and between the change in PELOD-2 score from day 1 and outcome.
resultsWe included 3669 patients (median age 15.5 months, mortality rate 6.1%, median length of PICU stay 3 days). Median dPELOD-2 scores were significantly higher in nonsurvivors than in survivors (p < 0.0001). The dPELOD-2 score was available at least at day 2 in 2057 patients: among the 796 patients without MODS on day 1, 186 (23.3%) acquired the syndrome during their PICU stay (mortality 4.9% vs. 0.3% among the 610 who did not; p < 0.0001). Among the 1261 patients with MODS on day 1, the syndrome worsened in 157 (12.4%) and remained unchanged or improved in 1104 (87.6%) (mortality 22.9% vs. 6.6%; p < 0.0001). The AUC of the dPELOD-2 scores ranged from 0.75 (95% CI: 0.67-0.83) to 0.89 (95% CI: 0.86-0.91). The calibration was good with a chi-square test between 13.5 (p = 0.06) and 0.9 (p = 0.99). The PELOD-2 score on day 1 was a significant prognostic factor; the serial evaluation of the change in the dPELOD-2 score from day1, adjusted for baseline value, demonstrated a significant odds ratio of death for each of the 7 days.
conclusionThis study suggests that the progression of the severity of organ dysfunctions can be evaluated by measuring the dPELOD-2 score during a set of 7 days in PICU, providing useful information on outcome in critically ill children. Its external validation would be useful.
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