ArticleMycopathologia2016
Molecular Characterization and In Vitro Antifungal Susceptibility of 316 Clinical Isolates of Dermatophytes in Iran.
Article in Mycopathologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 74 citations in OpenAlex.
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- Shifting etiological agents of dermatophytosis: a molecular epidemiological study from Iran.Iranian journal of microbiology · 2025Article
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- Descriptive epidemiology of dermatophytosis in rodents.Veterinary medicine and science · 2023Article
- Species Distribution and Antifungal Susceptibility Profile of Dermatophytes from a Tertiary Care Centre in North India.Journal of laboratory physicians · 2022Article
- Epidemiology of Dermatophytosis in Tehran, Iran: A Ten-year Retrospective Study.Archives of Iranian medicine · 2022Article
- Molecular study and antifungal susceptibility profile ofIranian journal of microbiology · 2022Article
- Molecular diagnosis of dermatophyte isolates from canine and feline dermatophytosis in Northeast Iran.Veterinary medicine and science · 2022Article
- Discovery of NewMicrobiology spectrum · 2021Article
- Prevalence of superficial-cutaneous fungal infections in Shiraz, Iran: A five-year retrospective study (2015-2019).Journal of clinical laboratory analysis · 2021Article
- Molecular Epidemiology and Antifungal Susceptibility ofJournal of fungi (Basel, Switzerland) · 2021Article
- Regional Differences in Antifungal Susceptibility of the Prevalent Dermatophyte Trichophyton rubrum.Mycopathologia · 2021Article
- Familial Cases of Trichophyton benhamiae Infection Transmitted from a Guinea Pig in Iran.Mycopathologia · 2021Article
- Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis PathogenClinical, cosmetic and investigational dermatology · 2021Article
- In-Vitro Activity of Nano Fluconazole and Conventional Fluconazole against Clinically Important Dermatophytes.Iranian journal of public health · 2020Article
- MIC and Upper Limit of Wild-Type Distribution for 13 Antifungal Agents against a Trichophyton mentagrophytes-Trichophyton interdigitale Complex of Indian Origin.Antimicrobial agents and chemotherapy · 2020Article
- LowCurrent medical mycology · 2020Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dermatophytosis is a common mycotic infection of the skin, nail, and hair, associated with major public health concern worldwide. Various species of dermatophytes show significant differences in susceptibility to antifungals. Here, we present the antifungal susceptibility of a large collection of molecularly identified dermatophyte isolates obtained from tropical region of south of Iran. A total of 9485 patients clinically suspected to have cutaneous fungal infections were examined. Dermatophytosis was confirmed in 1502 cases by direct microscopy and culture. Three hundred and sixteen isolates recovered in culture were identified to species level using PCR sequencing of ITS region and RFLP. Tinea corporis was the most prevalent type of clinical manifestation (35.2 %), followed by tinea cruris (17 %), tinea capitis (12.8 %), tinea pedis (11.3 %), tinea manuum (11 %), tinea unguium (6.9 %), and tinea barbae (5.8 %). Trichophyton interdigitale was the most common isolate (49.36 %), followed by Trichophyton rubrum (18.98 %), Epidermophyton floccosum (13.29 %), Microsporum canis (9.17 %), Arthroderma benhamiae (T. anamorph of A. benhamiae; 5.38 %), and Trichophyton tonsurans (3.79 %). Overall, irrespective of the geographical region, terbinafine was the most potent antifungal against all isolates, with an MIC range of 0.002-0.25 μg/mL, followed by itraconazole (0.004-0.5 μg/mL), griseofulvin (0.125-8 μg/mL), and fluconazole (4-128 μg/mL). Analysis of our data revealed a significant increase in the frequency of A.benhamiae, which definitely warrants further investigation to explore source of this infection in south of Iran. Moreover, terbinafine was the most effective antifungal against all isolates, in vitro.
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