ArticleJournal of bone and mineral metabolism2016
Identification of a progenitor cell population destined to form fracture fibrocartilage callus in Dickkopf-related protein 3-green fluorescent protein reporter mice.
Article in Journal of bone and mineral metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Pooled it
- TiNbSn stems with gradient changes of Young's modulus and stiffness reduce stress shielding compared to the standard fit-and-fill stems.European journal of medical research · 2023Trial
- Cemented total hip arthroplasty reduces early complications: a Japanese nationwide propensity-matched study.Archives of orthopaedic and trauma surgery · 2026Article
- Mechanobiological Implications of Low-Young's Modulus TiNbSn Alloy Plates for Fracture Fixation: A Focused Review.Medical sciences (Basel, Switzerland) · 2026Review
- Postoperative risk profile in elderly hip fracture patients undergoing chronic hemodialysis based on a nationwide database investigation.Scientific reports · 2025Article
- Scaffold-Free Bone Regeneration Through Collaboration Between Type IV Collagen and FBXL14.Journal of clinical medicine · 2025Article
- Postoperative risks of type 2 diabetes in elderly hip fracture patients: a propensity score-matched study.Journal of bone and mineral metabolism · 2025Article
- Mechanosensitive protein polycystin-1 promotes periosteal stem/progenitor cells osteochondral differentiation in fracture healing.Theranostics · 2024Article
- A Review of Anodized TiNbSn Alloys for Improvement in Layer Quality and Application to Orthopedic Implants.Materials (Basel, Switzerland) · 2022Review
- Identification of Key Genes and Pathways Associated withInternational journal of molecular sciences · 2022Article
- Article
- A Review of Recent Developments in the Molecular Mechanisms of Bone Healing.International journal of molecular sciences · 2021Review
- Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing.Science advances · 2020Article
- Article
- Bone secreted factors induce cellular quiescence in prostate cancer cells.Scientific reports · 2019Article
- Dickkopf-3 in aberrant endothelial secretome triggers renal fibroblast activation and endothelial-mesenchymal transition.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Article
- Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fracture healing is a complex biological process involving the proliferation of mesenchymal progenitor cells, and chondrogenic, osteogenic, and angiogenic differentiation. The mechanisms underlying the proliferation and differentiation of mesenchymal progenitor cells remain unclear. Here, we demonstrate Dickkopf-related protein 3 (Dkk3) expression in periosteal cells using Dkk3-green fluorescent protein reporter mice. We found that proliferation of mesenchymal progenitor cells began in the periosteum, involving Dkk3-positive cell proliferation near the fracture site. In addition, Dkk3 was expressed in fibrocartilage cells together with smooth muscle α-actin and Col3.6 in the early phase of fracture healing as a cell marker of fibrocartilage cells. Dkk3 was not expressed in mature chondrogenic cells or osteogenic cells. Transient expression of Dkk3 disappeared in the late phase of fracture healing, except in the superficial periosteal area of fracture callus. The Dkk3 expression pattern differed in newly formed type IV collagen positive blood vessels and the related avascular tissue. This is the first report that shows Dkk3 expression in the periosteum at a resting state and in fibrocartilage cells during the fracture healing process, which was associated with smooth muscle α-actin and Col3.6 expression in mesenchymal progenitor cells. These fluorescent mesenchymal lineage cells may be useful for future studies to better understand fracture healing.
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Registered trials
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