ArticleNature communications2015
The fatty acid elongase Bond is essential for Drosophila sex pheromone synthesis and male fertility.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility ineLife · 2023Article
- Transcriptional programs are activated and microRNAs are repressed within minutes after mating in the Drosophila melanogaster female reproductive tract.BMC genomics · 2023Article
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- Repression precedes independent evolutionary gains of a highly specific gene expression pattern.Cell reports · 2021Article
- Social perception of young adults prolongs the lifespan of aged Drosophila.NPJ aging and mechanisms of disease · 2021Article
- Candidate genes involved in cuticular hydrocarbon differentiation between cryptic, parabiotic ant species.G3 (Bethesda, Md.) · 2021Article
- A complete enzymatic capacity for biosynthesis of docosahexaenoic acid (DHA, 22 : 6n-3) exists in the marine Harpacticoida copepodOpen biology · 2021Article
- Sequencing, Expression, and Functional Analyses of Four Genes Related to Fatty Acid Biosynthesis During the Diapause Process in the Female Ladybird,Frontiers in physiology · 2021Article
- Effects of Diallyl Trisulfide, an Active Substance from Garlic Essential Oil, on Energy Metabolism in Male MothInsects · 2020Article
- N-glycosylation Site Analysis Reveals Sex-related Differences in Protein N-glycosylation in the Rice Brown Planthopper (Molecular & cellular proteomics : MCP · 2020Article
- Contact-Chemosensory Evolution Underlying Reproductive Isolation inFrontiers in behavioral neuroscience · 2020Review
- Age at onset of different pubertal signs in boys and girls and differential DNA methylation at age 10 and 18 years: an epigenome-wide follow-up study.Human reproduction open · 2020Article
- Evolution of Reproductive Behavior.Genetics · 2020Review
- Article
- Chemical Cues that Guide Female Reproduction in Drosophila melanogaster.Journal of chemical ecology · 2018Review
- Steroid Hormone Signaling Is Essential for Pheromone Production and Oenocyte Survival.PLoS genetics · 2016Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insects use a spectacular variety of chemical signals to guide their social behaviours. How such chemical diversity arises is a long-standing problem in evolutionary biology. Here we describe the contribution of the fatty acid elongase Bond to both pheromone diversity and male fertility in Drosophila. Genetic manipulation and mass spectrometry analysis reveal that the loss of bond eliminates the male sex pheromone (3R,11Z,19Z)-3-acetoxy-11,19-octacosadien-1-ol (CH503). Unexpectedly, silencing bond expression severely suppresses male fertility and the fertility of conspecific rivals. These deficits are rescued on ectopic expression of bond in the male reproductive system. A comparative analysis across six Drosophila species shows that the gain of a novel transcription initiation site is correlated with bond expression in the ejaculatory bulb, a primary site of male pheromone production. Taken together, these results indicate that modification of cis-regulatory elements and subsequent changes in gene expression pattern is one mechanism by which pheromone diversity arises.
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