ArticlePloS one2015
Effect of Calcifications on Breast Ultrasound Shear Wave Elastography: An Investigational Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Trial
- Visualisation of magnetic field-induced nanoparticle clusters and mechanical property changes in a breast phantom for inductive moderate hyperthermia.Biomedical engineering online · 2026Article
- Methodological considerations and technical limitations in the evaluation of ESWL success using SWE.Urolithiasis · 2025Article
- Clinical Significance of Ultrasound Elastography and Fibrotic Focus and Their Association in Breast Cancer.Journal of clinical medicine · 2022Article
- Added value of mass characteristic frequency to 2-D shear wave elastography for differentiation of benign and malignant thyroid nodules.Ultrasound in medicine & biology · 2022Article
- Hybrid high-definition microvessel imaging/shear wave elastography improves breast lesion characterization.Breast cancer research : BCR · 2022Article
- Prediction of Invasive Breast Cancer Using Mass Characteristic Frequency and Elasticity in Correlation with Prognostic Histologic Features and Immunohistochemical Biomarkers.Ultrasound in medicine & biology · 2021Article
- Role of "Stiff Rim" sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer.International journal of medical sciences · 2021Article
- Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses.Breast (Edinburgh, Scotland) · 2020Article
- Ultrasound elastography using a regularized modified error in constitutive equations (MECE) approach: a comprehensive phantom study.Physics in medicine and biology · 2020Article
- Article
- Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?Sensors (Basel, Switzerland) · 2020Review
- Incidental thoracic, hepatic and peritoneal calcifications: a case of Pentastomiasis.BJR case reports · 2019Article
- Differentiation of Benign and Malignant Thyroid Nodules by Using Comb-push Ultrasound Shear Elastography: A Preliminary Two-plane View Study.Academic radiology · 2018Article
- Shear wave elastography in the diagnosis of breast non-mass lesions: factors associated with false negative and false positive results.European radiology · 2017Article
- Value of shear wave arrival time contour display in shear wave elastography for breast masses diagnosis.Scientific reports · 2017Article
- Diagnostic features of quantitative comb-push shear elastography for breast lesion differentiation.PloS one · 2017Article
- Fully Automated and Robust Tracking of Transient Waves in Structured Anatomies Using Dynamic Programming.Ultrasound in medicine & biology · 2016Article
- Article
- Correction: Effect of Calcifications on Breast Ultrasound Shear Wave Elastography: An Investigational Study.PloS one · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the effects of macrocalcifications and clustered microcalcifications associated with benign breast masses on shear wave elastography (SWE).
methodsSuperSonic Imagine (SSI) and comb-push ultrasound shear elastography (CUSE) were performed on three sets of phantoms to investigate how calcifications of different sizes and distributions influence measured elasticity. To demonstrate the effect in vivo, three female patients with benign breast masses associated with mammographically-identified calcifications were evaluated by CUSE.
resultsApparent maximum elasticity (Emax) estimates resulting from individual macrocalcifications (with diameters of 2mm, 3mm, 5mm, 6mm, 9mm, 11mm, and 15mm) showed values over 50 kPa for all cases, which represents more than 100% increase over background (~21kPa). We considered a 2cm-diameter circular region of interest for all phantom experiments. Mean elasticity (Emean) values varied from 26 kPa to 73 kPa, depending on the macrocalcification size. Highly dense clusters of microcalcifications showed higher Emax values than clusters of microcalcification with low concentrations, but the difference in Emean values was not significant.
conclusionsOur results demonstrate that the presence of large isolated macrocalcifications and highly concentrated clusters of microcalcifications can introduce areas with apparent high elasticity in SWE. Considering that benign breast masses normally have significantly lower elasticity values than malignant tumors, such areas with high elasticity appearing due to presence of calcification in benign breast masses may lead to misdiagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.