Trial reportPloS one2015
Magnetoencephalography Reveals a Widespread Increase in Network Connectivity in Idiopathic/Genetic Generalized Epilepsy.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
- Comprehensive evaluation of EEG spatial sampling, head modelling and parcellation effects on network alterations in idiopathic generalized epilepsy.Brain communications · 2026Article
- Quantitative EEG signatures in patients with and without epilepsy development after a first seizure.Epilepsia open · 2025Article
- Quantitative analysis of the resting-state EEG power spectrum in patients with epilepsy comorbid with anxiety and depression.Acta epileptologica · 2025Article
- Brain Connectivity Yields Insights into the Pathogenesis of Epilepsy and Subtypes: Evidence from Mendelian Randomization Analysis.Health data science · 2025Article
- Transient destabilization of interhemispheric functional connectivity induced by spreading depolarization.Network neuroscience (Cambridge, Mass.) · 2024Article
- Adult lifespan trajectories of neuromagnetic signals and interrelations with cortical thickness.NeuroImage · 2023Review
- Neuronal networks underlying ictal and subclinical discharges in childhood absence epilepsy.Journal of neurology · 2023Article
- Altered neuromagnetic activity in default mode network in childhood absence epilepsy.Frontiers in neuroscience · 2023Article
- Is Functional Connectivity after a First Unprovoked Seizure Different Based on Subsequent Seizures and Future Diagnosis of Epilepsy?Journal of epilepsy research · 2022Article
- Genetic generalized epilepsies in adults - challenging assumptions and dogmas.Nature reviews. Neurology · 2022Review
- Contributions of Magnetoencephalography to Understanding Mechanisms of Generalized Epilepsies: Blurring the Boundary Between Focal and Generalized Epilepsies?Frontiers in neurology · 2022Review
- Networks of cortical activity in infants with epilepsy.Brain communications · 2022Article
- MEG Node Degree Differences in Patients with Focal Epilepsy vs. Controls-Influence of Experimental Conditions.Brain sciences · 2021Article
- Localizing the Epileptogenic Zone with Novel Biomarkers.Seminars in pediatric neurology · 2021Review
- Heritability of Magnetoencephalography Phenotypes Among Patients With Genetic Generalized Epilepsy and Their Siblings.Neurology · 2021Article
- Epileptiform discharges relate to altered functional brain networks in autism spectrum disorders.Brain communications · 2021Article
- Altered Resting-State Electroencephalography Microstates in Idiopathic Generalized Epilepsy: A Prospective Case-Control Study.Frontiers in neurology · 2021Article
- Presurgical Evaluation of Epilepsy Using Resting-State MEG Functional Connectivity.Frontiers in human neuroscience · 2021Review
- Functional network topology in drug resistant and well-controlled idiopathic generalized epilepsy: a resting state functional MRI study.Brain communications · 2021Article
- Specific Oscillatory Power Changes and Their Efficacy for Determining Laterality in Mesial Temporal Lobe Epilepsy: A Magnetoencephalographic Study.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic/genetic generalized epilepsy (IGE/GGE) is characterized by seizures, which start and rapidly engage widely distributed networks, and result in symptoms such as absences, generalized myoclonic and primary generalized tonic-clonic seizures. Although routine magnetic resonance imaging is apparently normal, many studies have reported structural alterations in IGE/GGE patients using diffusion tensor imaging and voxel-based morphometry. Changes have also been reported in functional networks during generalized spike wave discharges. However, network function in the resting-state without epileptiforme discharges has been less well studied. We hypothesize that resting-state networks are more representative of the underlying pathophysiology and abnormal network synchrony. We studied functional network connectivity derived from whole-brain magnetoencephalography recordings in thirteen IGE/GGE and nineteen healthy controls. Using graph theoretical network analysis, we found a widespread increase in connectivity in patients compared to controls. These changes were most pronounced in the motor network, the mesio-frontal and temporal cortex. We did not, however, find any significant difference between the normalized clustering coefficients, indicating preserved gross network architecture. Our findings suggest that increased resting state connectivity could be an important factor for seizure spread and/or generation in IGE/GGE, and could serve as a biomarker for the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.