ArticlePloS one2015
Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: Implication of Hippocampal BDNF and CREB.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Implications of Physical Exercise on Episodic Memory and Anxiety: The Role of the Serotonergic System.International journal of molecular sciences · 2023Review
- Recent insights into autophagy and metals/nanoparticles exposure.Toxicological research · 2023Review
- Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs.Frontiers in toxicology · 2023Review
- Fenugreek seed powder protects mice against arsenic-induced neurobehavioral changes.Current research in toxicology · 2023Article
- The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1.Iranian journal of basic medical sciences · 2021Article
- Resveratrol attenuates arsenic-induced cognitive deficits via modulation of Estrogen-NMDAR-BDNF signalling pathway in female mouse hippocampus.Psychopharmacology · 2021Article
- High fat diet deteriorates the memory impairment induced by arsenic in mice: a sub chronic in vivo study.Metabolic brain disease · 2019Article
- Protective effect of gallic acid against arsenic-induced anxiety-/depression- like behaviors and memory impairment in male rats.Metabolic brain disease · 2019Article
- Prevention of Deficit in Neuropsychiatric Disorders through Monitoring of Arsenic and Its Derivatives as Well as Through Bioinformatics and Cheminformatics.International journal of molecular sciences · 2019Review
- Blood heavy metals and brain-derived neurotrophic factor in the first trimester of pregnancy among migrant workers.PloS one · 2019Article
- Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats.International journal of molecular sciences · 2018Article
- Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity.Scientific reports · 2018Article
- Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum.Molecular neurobiology · 2018Article
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High concentrations of arsenic, which can be occasionally found in drinking water, have been recognized as a global health problem. Exposure to arsenic can disrupt spatial memory; however, the underlying mechanism remains unclear. In the present study, we tested whether exercise could interfere with the effect of arsenic exposure on the long-term memory (LTM) of object recognition in mice. Arsenic (0, 1, 3, and 10 mg/ kg, i.g.) was administered daily for 12 weeks. We found that arsenic at dosages of 1, 3, and 10 mg/kg decreased body weight and increased the arsenic content in the brain. The object recognition LTM (tested 24 h after training) was disrupted by 3 mg/ kg and 10 mg/ kg, but not 1 mg/ kg arsenic exposure. Swimming exercise also prevented LTM impairment induced by 3 mg/ kg, but not with 10 mg/ kg, of arsenic exposure. The expression of brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP-response element binding protein (pCREB) in the CA1 and dentate gyrus areas (DG) of the dorsal hippocampus were decreased by 3 mg/ kg and 10 mg/ kg, but not by 1 mg/ kg, of arsenic exposure. The decrease in BDNF and pCREB in the CA1 and DG induced by 3 mg/ kg, but not 10 mg/ kg, of arsenic exposure were prevented by swimming exercise. Arsenic exposure did not affect the total CREB expression in the CA1 or DG. Taken together, these results indicated that swimming exercise prevented the impairment of object recognition LTM induced by arsenic exposure, which may be mediated by BDNF and CREB in the dorsal hippocampus.
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