Trial reportPloS one2015
The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Sphingosine-1-Phosphate, a Marker of Endothelial Injury and Disease Severity in Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Early Prediction of Hypertensive Diseases of Pregnancy by Using Combined Screening Methods in a Rural Population.Cureus · 2023Article
- Article
- Pregnant alpha-1-microglobulin (A1M) knockout mice exhibit features of kidney and placental damage, hemodynamic changes and intrauterine growth restriction.Scientific reports · 2020Article
- The Role of αInternational journal of molecular sciences · 2020Review
- Maternal plasma proteomics in a rat model of pregnancy complications reveals immune and pro-coagulant gene pathway activation.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Article
- αFrontiers in physiology · 2020Article
- Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction.PloS one · 2020Observational
- Protection of Kidney Function with Human Antioxidation Protein αAntioxidants & redox signaling · 2019Review
- Different morphological and gene expression profile in placentas of the same sickle cell anemia patient in pregnancies of opposite outcomes.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- rA1M-035, a Physicochemically Improved Human Recombinant αAntioxidants & redox signaling · 2019Article
- Article
- Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies.Frontiers in physiology · 2019Article
- αFrontiers in physiology · 2018Article
- Article
- Urinary Extracellular Vesicles of Podocyte Origin and Renal Injury in Preeclampsia.Journal of the American Society of Nephrology : JASN · 2017Article
- Heme-mediated apoptosis and fusion damage in BeWo trophoblast cells.Scientific reports · 2016Article
- Red cell DAMPs and inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia (PE) complicates 3-8% of all pregnancies and manifests clinically as hypertension and proteinuria in the second half of gestation. The pathogenesis of PE is not fully understood but recent studies have described the involvement of cell-free fetal hemoglobin (HbF). Hypothesizing that PE is associated with prolonged hemolysis we have studied the response of the cell-free Hb- and heme defense network. Thus, we have investigated the levels of cell-free HbF (both free, denoted HbF, and in complex with Hp, denoted Hp-HbF) as well as the major human endogenous Hb- and heme-scavenging systems: haptoglobin (Hp), hemopexin (Hpx), α1-microglobulin (A1M) and CD163 in plasma of PE women (n = 98) and women with normal pregnancies (n = 47) at term. A significant increase of the mean plasma HbF concentration was observed in women with PE. Plasma levels of Hp and Hpx were statistically significantly reduced, whereas the level of the extravascular heme- and radical scavenger A1M was significantly increased in plasma of women with PE. The Hpx levels significantly correlated with maternal blood pressure. Furthermore, HbF and the related scavenger proteins displayed a potential to be used as clinical biomarkers for more precise diagnosis of PE and are candidates as predictors of identifying pregnancies with increased risk of obstetrical complications. The results support that PE pathophysiology is associated with increased HbF-concentrations and an activation of the physiological Hb-heme defense systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.