Trial reportPloS one2015
The Association of Handgrip Strength and Type 2 Diabetes Mellitus in Six Ethnic Groups: An Analysis of the HELIUS Study.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Global variation in grip strength: a systematic review and meta-analysis of normative data.Age and ageing · 2016Pooled it
- Effects of a lifestyle intervention programme after 1 year of follow-up among South Asians at high risk of type 2 diabetes: a cluster randomised controlled trial.BMJ global health · 2021Trial
- Cross-cohort insights into the association of handgrip strength transitions and burdens with cardiovascular disease risk.SSM - population health · 2026Article
- Cross-cohort insights into the association of handgrip strength transitions and burdens with cardiovascular disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Relationship between sarcopenia and type 2 diabetes mellitus among adults with prediabetes: evidence from a prospective cohort study.Diabetology & metabolic syndrome · 2025Article
- Muscle Strength, Genetic Risk, and Type 2 Diabetes Among Individuals of South Asian Ancestry: A UK Biobank Study.Journal of diabetes · 2025Article
- The Relationship Between Health Parameters, Body Size, Elements of Lifestyle, and Hand Grip Strength in a Group of Patients with Type 2 Diabetes, Aged 40-98, from Ulaanbaatar, Mongolia.Journal of clinical medicine · 2024Article
- Performance of different machine learning algorithms in identifying undiagnosed diabetes based on nonlaboratory parameters and the influence of muscle strength: A cross-sectional study.Journal of diabetes investigation · 2024Article
- Hand grip strength as a proposed new vital sign of health: a narrative review of evidences.Journal of health, population, and nutrition · 2024Review
- Association of relative handgrip strength on the development of diabetes mellitus in elderly Koreans.PloS one · 2024Article
- Prediabetes-Associated Changes in Skeletal Muscle Function and Their Possible Links with Diabetes: A Literature Review.International journal of molecular sciences · 2023Review
- Association between Grip Strength, Obesity, and Cardiometabolic Risk Factors among the Community-Dwelling Elderly Population in Taiwan.International journal of environmental research and public health · 2022Article
- Multimorbidity Accumulation Among Middle-Aged Americans: Differences by Race/Ethnicity and Body Mass Index.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Association between Handgrip Strength and Cognitive Function in Older Adults: Korean Longitudinal Study of Aging (2006-2018).International journal of environmental research and public health · 2022Article
- Lower handgrip strength levels probably precede triglyceride glucose index and associated with diabetes in men not in women.Journal of diabetes investigation · 2022Article
- Low relative hand grip strength is associated with a higher risk for diabetes and impaired fasting glucose among the Korean population.PloS one · 2022Article
- Physical Activity and Dietary Composition Relate to Differences in Gut Microbial Patterns in a Multi-Ethnic Cohort-The HELIUS Study.Metabolites · 2021Article
- Relative handgrip strength is inversely associated with the presence of type 2 diabetes in overweight elderly women with varying nutritional status.Acta diabetologica · 2021Article
- Association of Hand Grip Strength and Cardiometabolic Markers in Korean Adult Population: The Korea National Health and Nutrition Examination Survey 2015-2016.Korean journal of family medicine · 2020Article
- Glucose Levels as a Mediator of the Detrimental Effect of Abdominal Obesity on Relative Handgrip Strength in Older Adults.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated whether ethnic differences in handgrip strength, a marker of poor muscle strength and quality, is a potential cause of ethnic disparities in type 2 diabetes mellitus. We included 2086 Dutch, 2216 South Asian Surinamese, 2084 African Surinamese, 1786 Ghanaian, 2223 Turkish and 2199 Moroccan origin participants from the HELIUS study. We analyzed ethnic differences in handgrip strength, and its association with type 2 diabetes mellitus using logistic regression analyses adjusted for socio-demographic factors, body composition and lifestyle factors. Additionally, we investigated whether handgrip strength explained the ethnic differences in type 2 diabetes mellitus. We found that handgrip strength differed significantly across ethnic groups. After full adjustment, we found an inverse association with type 2 diabetes mellitus (OR 0.95; 95% CI 0.92-0.97) that did not differ substantially between ethnic groups, men and among women, and lean and overweight individuals. The association was not affected by the measure used to define type 2 diabetes mellitus, but was attenuated by exclusion of people with known diabetes. The ethnic differences in type 2 diabetes mellitus were not explained by handgrip strength (e.g. the OR for the South Asian Surinamese vs. Dutch changed from 5.03; 3.69-6.68 to 4.87; 3.57-6.65). In conclusion, we found large ethnic differences in handgrip strength and a consistent association of low handgrip strength with prevalent type 2 diabetes mellitus. This suggests that handgrip strength may be investigated as a target for intervention or a marker to identify people at risk of type 2 diabetes mellitus.
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