ArticlePloS one2015
Fat Grafting in Burn Scar Alleviates Neuropathic Pain via Anti-Inflammation Effect in Scar and Spinal Cord.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Autologous fat grafting to the paravertebral space seems to prevent the postherpetic neuralgia-A single-arm pilot study.Brain and behavior · 2023Trial
- Neuromodulation strategies in postburn care for pain rehabilitation and scar remodelling.Communications medicine · 2026Review
- ( +)-Catechin Alleviates CCI-Induced Neuropathic Pain by Modulating Microglia M1 and M2 Polarization via the TLR4/MyD88/NF-κB Signaling Pathway.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Autologous fat grafting for management of pain at spinal cord implantable pulse generator sites.JPRAS open · 2025Article
- Burn scar pain: from mechanisms to treatments.Frontiers in physiology · 2025Review
- Comparative Analysis of a New Automatic System and Four Existing Techniques for Autologous Fat Grafting.Plastic and reconstructive surgery. Global open · 2023Article
- Advancements in adipose-derived stem cell therapy for skin fibrosis.World journal of stem cells · 2023Review
- Preparation, Characterization of Pregabalin andGels (Basel, Switzerland) · 2022Article
- Effects of multiple modes of UltraPulse fractional COLasers in medical science · 2022Article
- Adipose-Derived Stem Cell-Incubated HA-Rich Sponge Matrix Implant Modulates Oxidative Stress to Enhance VEGF and TGF-Oxidative medicine and cellular longevity · 2022Article
- Irisin Gene Delivery Ameliorates Burn-Induced Sensory and Motor Neuropathy.International journal of molecular sciences · 2020Article
- Microglial-induced apoptosis is potentially responsible for hyperalgesia variations during CFA-induced inflammation.Inflammopharmacology · 2020Article
- Treatment of chronic post-herpetic neuralgia with autologous fat grafts: a first-in-the-world case report.British journal of pain · 2019Article
- Inhibition of LPS-Induced Oxidative Damages and Potential Anti-Inflammatory Effects ofAntioxidants (Basel, Switzerland) · 2019Article
- Platelet-Rich Plasma Injection in Burn Scar Areas Alleviates Neuropathic Scar Pain.International journal of medical sciences · 2018Article
- Autologous Adipose-Derived Stem Cells Reduce Burn-Induced Neuropathic Pain in a Rat Model.International journal of molecular sciences · 2017Article
- The power of fat and its adipose-derived stromal cells: emerging concepts for fibrotic scar treatment.Journal of tissue engineering and regenerative medicine · 2017Review
- Peripheral Neuropathy and Nerve Compression Syndromes in Burns.Clinics in plastic surgery · 2017Review
- What is the optimal sequence of decompression for multilevel noncontinuous spinal cord compression injuries in rabbits?BMC neurology · 2017Article
- A Unique Case of Allogeneic Fat Grafting Between Brothers.Plastic and reconstructive surgery. Global open · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burn-induced neuropathic pain is complex, and fat grafting has reportedly improved neuropathic pain. However, the mechanism of fat grafting in improving neuropathic pain is unclear. Previous investigations have found that neuroinflammation causes neuropathic pain, and anti-inflammatory targeting may provide potential therapeutic opportunities in neuropathic pain. We hypothesized that fat grafting in burn scars improves the neuropathic pain through anti-inflammation. Burn-induced scar pain was confirmed using a mechanical response test 4 weeks after burn injuries, and autologous fat grafting in the scar area was performed simultaneously. After 4 weeks, the animals were sacrificed, and specimens were collected for the inflammation test, including COX-2, iNOS, and nNOS in the injured skin and spinal cord dorsal horns through immunohistochemistry and Western assays. Furthermore, pro-inflammatory cytokines (IL-1 β and TNF-α) in the spinal cord were collected. Double immunofluorescent staining images for measuring p-IκB, p-NFκB, p-JNK, and TUNEL as well as Western blots of AKT, Bax/Bcl-2 for the inflammatory process, and apoptosis were analyzed. Fat grafting significantly reduced COX2, nNOS, and iNOS in the skin and spinal cord dorsal horns, as well as IL-1β and TNF-α, compared with the burn group. Moreover, regarding the anti-inflammatory effect, the apoptosis cells in the spinal cord significantly decreased after the fat grafting in the burn injury group. Fat grafting was effective in treating burn-induced neuropathic pain through the alleviation of neuroinflammation and ameliorated spinal neuronal apoptosis.
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