Trial reportPloS one2015
HIF2A Variants Were Associated with Different Levels of High-Altitude Hypoxia among Native Tibetans.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- EPAS1 is associated with human muscle fiber composition and endurance phenotypes.Physiological reports · 2026Article
- Association between single nucleotide polymorphisms inFrontiers in genetics · 2025Article
- Evolution of Key Oxygen-Sensing Genes Is Associated with Hypoxia Tolerance in Fishes.Genome biology and evolution · 2024Article
- Relationship between Hypoxia and Hypercapnia Tolerance and Life Expectancy.International journal of molecular sciences · 2024Review
- Novel insight into the genetic signatures of altitude adaptation related body composition in Tibetans.Frontiers in public health · 2024Article
- The role ofHeliyon · 2023Article
- A Study on the Molecular Mechanism of High Altitude Heart Disease in Children.Pharmacogenomics and personalized medicine · 2022Review
- Evaluation of bone metabolism-associated biomarkers in Tibet, China.Journal of clinical laboratory analysis · 2021Article
- The Genetics of Sleep Disorders in Children: A Narrative Review.Brain sciences · 2021Review
- Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation.Frontiers in cell and developmental biology · 2021Review
- EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study.Military Medical Research · 2020Article
- Demographic History and Genetic Adaptation in the Himalayan Region Inferred from Genome-Wide SNP Genotypes of 49 Populations.Molecular biology and evolution · 2018Article
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia.The Journal of clinical investigation · 2018Article
- Article
- SNPs, linkage disequilibrium, and chronic mountain sickness in Tibetan Chinese.Hypoxia (Auckland, N.Z.) · 2017Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia inducible factors, including HIF1A and HIF2A, play central roles in response to high-altitude hypoxia and genetic variants of HIF1A or HIF2A were associated with high-altitude sickness or adaptation. However, it remains to determine whether they are associated with tolerance to different levels of high-altitude selection pressure among native Tibetans. We recruited 189 Tibetan subjects living at 2,700 meters (Low level of high altitude, LHA), 197 at 3,200 meters (Middle level of high altitude of high altitude, MHA), 249 at 3,700 meters (High level of high altitude, HHA) and 269 at 4,700 meters (Very high level of high altitude, VHA) and performed association analysis of twelve tSNPs (tagging SNPs) in HIF1A and HIF2A with high-altitude. We found (1) a increasing trend of HIF2A rs5621780-C(18.4%, 15.9%, 32.8% and 31.1%, respectively, in LHA, MHA, HHA and VHA)(P = 3.56E-9); (2) increasing trends of HIF2A rs6756667-A(68.7%, 73.4%, 79.9% and 89.6%), rs7589621- G(74.6%, 77.9%, 83.7%, and 92.1%) and rs1868092-A(64.1%, 67.3%, 75.1% and 84.4%) (P = 3.56E-9, 4.68E-16, 1.17E-13 and 7.09E-14, respectively); (3) a increasing trend of haplotype AG (68.7%, 73.1%, 79.9% and 89.6%) (P = 2.22E-7) which was constructed by rs6756667 and rs7589621; (4) a strong linear correlation between major alleles of rs6756667-A (R2 = 0.997, P = 0.002), rs7589621-G (R2 = 0.994, P = 0.003), rs1868092-A (R2 = 0.985, P = 0.008) and altitude by linear correlation test. The associations between HIF2A variants and different level of high altitude support that extremely high-altitude hypoxia challenge imposes selective effects on HIF2A variants among native Tibetans.
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