Evidence map›Paper›PMID 26367502›Full record

ReviewRNA biology2015

Identification of the Drosophila X chromosome: The long and short of it.

Debashish U Menon, Victoria H Meller

Open access · hybridAbstract readReview
In one paragraph

Review in RNA biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Insects · 2021
    Article
  7. Article
  8. Functional Significance of Satellite DNAs: Insights FromFrontiers in cell and developmental biology · 2020
    Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Debashish U Menona Department of Genetics ; University of North Carolina ; Chapel Hill , NC USA.
Victoria H Mellerb Department of Biological Sciences ; Wayne State University ; Detroit , MI USA.
University of North Carolina at Chapel Hill · USWayne State University · US

Funding

Small RNA and whole chromosome recognition in Drosophila melanogaster.R01GM093110 · NIGMS · WAYNE STATE UNIVERSITY · PI MELLER, VICTORIA H · 2011 to 2019
$2.3M
NIGMS NIH HHS GM093110
6 · The paper itself

Abstract

The different dose of X chromosomes in males and females produces a potentially fatal imbalance in X-linked gene products. This imbalance is addressed by dosage compensation, a process that modulates expression from an entire X chromosome in one sex. Dosage compensation acts on thousands of genes with disparate expression patterns. Both flies and mammals accomplish this with remarkable specificity by targeting epigenetic chromatin modifications to a single chromosome. Long noncoding RNAs that are expressed from the X chromosome are essential elements of the targeting mechanism in both lineages. We recently discovered that the siRNA pathway, as well as small RNA from satellite repeats that are strikingly enriched on the fly X chromosome, also promote X recognition. In this article we review the current understanding of X recognition in flies and discuss potential mechanisms by which the siRNA pathway, repetitive elements and long noncoding RNAs might cooperate to promote X recognition.

Indexed as

Dosage Compensation, GeneticAnimalsChromatinDrosophila melanogasterEpigenesis, GeneticFemaleGene Expression Regulation, DevelopmentalMaleRNA, Long NoncodingRNA, Small InterferingX ChromosomeChromatinRNA, Long NoncodingRNA, Small Interfering1.688X repeats359 bp repeatsdosage compensationDrosophila melanogasterroX RNAsatellite repeatssiRNAX recognition

Identifiers

PMID26367502
PMCPMC4829311
OpenAlexW2198216962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.