ArticleThe Clinical neuropsychologist2015
Does Older Age Confer an Increased Risk of Incident Neurocognitive Disorders Among Persons Living with HIV Disease?
Article in The Clinical neuropsychologist, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Is There Any Evidence of Premature, Accentuated and Accelerated Aging Effects on Neurocognition in People Living with HIV? A Systematic Review.AIDS and behavior · 2021Pooled it
- A systematic review of prospective memory in HIV disease: from the laboratory to daily life.The Clinical neuropsychologist · 2018Pooled it
- Digital language measures capture episodic memory disruptions in people with human immunodeficiency virus: A machine learning study.The Clinical neuropsychologist · 2026Article
- Assessing neurocognitive functioning among adults ageing with and without HIV at the Kenyan Coast: measurement issues and correlates.Frontiers in aging neuroscience · 2025Article
- Twelve-year neurocognitive decline in HIV is associated with comorbidities, not age: a CHARTER study.Brain : a journal of neurology · 2023Article
- Factors associated with verbal fluency in older adults living with HIV in West Africa: A longitudinal study.Tropical medicine & international health : TM & IH · 2023Article
- Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Model.AIDS and behavior · 2022Article
- Combined effects of older age and HIV disease on changes in everyday functioning over one year.Journal of neurovirology · 2022Article
- Alzheimer Dementia in People Living With HIV.Neurology. Clinical practice · 2021Article
- Effects of Age, Level of Education and HIV Status on Cognitive Performance in West African Older Adults: The West Africa IeDEA Cohort Collaboration.AIDS and behavior · 2021Article
- Cognitive and motor deficits in older adults with HIV infection: Comparison with normal ageing and Parkinson's disease.Journal of neuropsychology · 2021Article
- Reliably Measuring Cognitive Change in the Era of Chronic HIV Infection and Chronic HIV-Associated Neurocognitive Disorders.Current topics in behavioral neurosciences · 2021Review
- Prospective memory partially mediates the association between aging and everyday functioning.The Clinical neuropsychologist · 2020Article
- One-year stability of prospective memory symptoms and performance in aging and HIV disease.Journal of clinical and experimental neuropsychology · 2020Article
- TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment.Journal of neuroinflammation · 2019Article
- Chronic Disease Onset Among People Living with HIV and AIDS in a Large Private Insurance Claims Dataset.Scientific reports · 2019Article
- The current understanding of overlap between characteristics of HIV-associated neurocognitive disorders and Alzheimer's disease.Journal of neurovirology · 2019Review
- Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats.Neurotoxicity research · 2019Article
- Cognitive Trajectory Phenotypes in Human Immunodeficiency Virus-Infected Patients.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- A culturally fair test of processing speed: Construct validity, preliminary normative data, and effects of HIV infection on performance in South African adults.Neuropsychology · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveThis study aimed to determine the combined effects of age and HIV infection on the risk of incident neurocognitive disorders.
methodA total of 146 neurocognitively normal participants were enrolled at baseline into one of four groups based on age (≤ 40 years and ≥ 50 years) and HIV serostatus resulting in 24 younger HIV-, 27 younger HIV+, 39 older HIV-, and 56 older HIV+ individuals. All participants were administered a standardized clinical neuropsychological battery at baseline and 14.3 ± .2 months later.
resultsA logistic regression predicting incident neurocognitive disorders from HIV, age group, and their interaction was significant (χ(2)[4] = 13.56, p = .009), with a significant main effect of HIV serostatus (χ(2)[1] = 5.01, p = .025), but no main effect of age or age by HIV interaction (ps > .10). Specifically, 15.7% of the HIV+ individuals had an incident neurocognitive disorder as compared to 3.2% of the HIV- group (odds ratio = 4.8 [1.2, 32.6]). Among older HIV+ adults, lower baseline cognitive reserve, prospective memory, and verbal fluency each predicted incident neurocognitive disorders at follow-up.
conclusionsIndependent of age, HIV infection confers a nearly fivefold risk for developing a neurocognitive disorder over approximately one year. Individuals with lower cognitive reserve and mild weaknesses in higher-order neurocognitive functions may be targeted for closer clinical monitoring and preventative measures.
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