Evidence map›Paper›PMID 26367120›Full record

ArticlePloS one2015

Cancer Mortality in People Treated with Antidepressants before Cancer Diagnosis: A Population Based Cohort Study.

Yuelian Sun, Peter Vedsted, Morten Fenger-Grøn, Chun Sen Wu, Bodil Hammer Bech, Jørn Olsen, Michael Eriksen Benros, Mogens Vestergaard

Erratum issuedAbstract read
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In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  10. Relationship between anti-depressant use and lung cancer survival.Cancer treatment and research communications · 2017
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yuelian SunResearch Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark; Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Peter VedstedResearch Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark.
Morten Fenger-GrønResearch Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark.
Chun Sen WuSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Bodil Hammer BechResearch Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark; Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Jørn OlsenSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Michael Eriksen BenrosPsychiatric Research Unit, Copenhagen University Hospital, Copenhagen, Denmark.
Mogens VestergaardResearch Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark; Section for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is common after a cancer diagnosis and is associated with an increased mortality, but it is unclear whether depression occurring before the cancer diagnosis affects cancer mortality. We aimed to study cancer mortality of people treated with antidepressants before cancer diagnosis. METHODS AND

findingsWe conducted a population based cohort study of all adults diagnosed with cancer between January 2003 and December 2010 in Denmark (N = 201,662). We obtained information on cancer from the Danish Cancer Registry, on the day of death from the Danish Civil Registry, and on redeemed antidepressants from the Danish National Prescription Registry. Current users of antidepressants were defined as those who redeemed the latest prescription of antidepressant 0-4 months before cancer diagnosis (irrespective of earlier prescriptions), and former users as those who redeemed the latest prescription five or more months before cancer diagnosis. We estimated an all-cause one-year mortality rate ratio (MRR) and a conditional five-year MRR for patients who survived the first year after cancer diagnosis and confidence interval (CI) using a Cox proportional hazards regression model. Overall, 33,111 (16.4%) patients redeemed at least one antidepressant prescription in the three years before cancer diagnosis of whom 21,851 (10.8%) were current users at the time of cancer diagnosis. Current antidepressant users had a 32% higher one-year mortality (MRR = 1.32, 95% CI: 1.29-1.35) and a 22% higher conditional five-year mortality (MRR = 1.22, 95% CI: 1.17-1.26) if patients survived the first year after the cancer diagnosis than patients not redeeming antidepressants. The one-year mortality was particularly high for patients who initiated antidepressant treatment within four months before cancer diagnosis (MRR = 1.54, 95% CI: 1.47-1.61). Former users had no increased cancer mortality.

conclusionsInitiation of antidepressive treatment prior to cancer diagnosis is common and is associated with an increased mortality.

Indexed as

RegistriesAdolescentAdultAgedAged, 80 and overAntidepressive AgentsFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasmsRetrospective StudiesSurvival RateTime FactorsAntidepressive Agents

Identifiers

PMID26367120
PMCPMC4569483

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.