Evidence map›Paper›PMID 26367118›Full record

ArticlePloS one2015

Mature Erythrocytes of Iguana iguana (Squamata, Iguanidae) Possess Functional Mitochondria.

Giuseppina Di Giacomo, Silvia Campello, Mauro Corrado, Livia Di Giambattista, Claudia Cirotti, Giuseppe Filomeni, Gabriele Gentile

Abstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giuseppina Di GiacomoDipartimento di Biologia, Università Tor Vergata, Roma, Italia.
Silvia CampelloDipartimento di Biologia, Università Tor Vergata, Roma, Italia; IRCCS Fondazione Santa Lucia, Roma, Italia.
Mauro CorradoIRCCS Fondazione Santa Lucia, Roma, Italia; Istituto Telethon Dulbecco, Istituto Veneto di Medicina Molecolare, Padova, Italia.
Livia Di GiambattistaDipartimento di Biologia, Università Tor Vergata, Roma, Italia.
Claudia CirottiDipartimento di Biologia, Università Tor Vergata, Roma, Italia.
Giuseppe FilomeniDipartimento di Biologia, Università Tor Vergata, Roma, Italia; Cell Stress and Survival Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
Gabriele GentileDipartimento di Biologia, Università Tor Vergata, Roma, Italia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electron microscopy analyses of Iguana iguana blood preparations revealed the presence of mitochondria within erythrocytes with well-structured cristae. Fluorescence microscopy analyses upon incubation with phalloidin-FITC, Hoechst 33342 and mitochondrial transmembrane potential (Δψm)-sensitive probe MitoTracker Red indicated that mitochondria i) widely occur in erythrocytes, ii) are polarized, and iii) seem to be preferentially confined at a "perinuclear" region, as confirmed by electron microscopy. The analysis of NADH-dependent oxygen consumption showed that red blood cells retain the capability to consume oxygen, thereby providing compelling evidence that mitochondria of Iguana erythrocytes are functional and capable to perform oxidative phosphorylation.

Indexed as

AnimalsErythrocytesIguanasMembrane Potential, MitochondrialMitochondriaNADOxidative PhosphorylationNAD

Identifiers

PMID26367118
PMCPMC4569276

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.