ArticleNature nanotechnology2015
Durable protein lattices of clathrin that can be functionalized with nanoparticles and active biomolecules.
Article in Nature nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Nanodissected elastically loaded clathrin lattices relax to increased curvature.Science advances · 2021Article
- Zwitterion Effect of Cow Brain Protein towards Efficiency Improvement of Dye-Sensitized Solar Cell (DSSC).TheScientificWorldJournal · 2020Article
- Dynamical Majorana edge modes in a broad class of topological mechanical systems.Nature communications · 2017Article
- Utilizing clathrin triskelions as carriers for spatially controlled multi-protein display.Biomaterials · 2016Article
- The Age of Cortical Neural Networks Affects Their Interactions with Magnetic Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- Concentration Dependent Ion-Protein Interaction Patterns Underlying Protein Oligomerization Behaviours.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological molecules that self-assemble and interact with other molecules are attractive building blocks for engineering biological devices. DNA has been widely used for the creation of nanomaterials, but the use of proteins remains largely unexplored. Here, we show that clathrin can form homogeneous and extended two-dimensional lattices on a variety of substrates, including glass, metal, carbon and plastic. Clathrin is a three-legged protein complex with unique self-assembling properties and is relevant in the formation of membrane transport vesicles in eukaryotic cells. We used a fragment of the adaptor protein epsin to immobilize clathrin lattices on the substrates. The lattices span multiple square millimetres with a regular periodicity of 30 nm and can be functionalized via modified subunits of clathrin with either inorganic nanoparticles or active enzymes. The lattices can be stored for months after crosslinking and stabilization with uranyl acetate. They could be dehydrated and rehydrated without loss of function, offering potential applications in sensing and as biosynthetic reactors.
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Registered trials
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