Evidence map›Paper›PMID 26366844›Full record

ReviewHuman vaccines & immunotherapeutics2015

Immunization of pregnant women: Future of early infant protection.

Azure N Faucette, Michael D Pawlitz, Bo Pei, Fayi Yao, Kang Chen

Abstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  6. Review
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  10. Observational
  11. Review
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  17. Article
  18. Maternal vaccination: A narrative review.Southern African journal of infectious diseases · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Azure N Faucettea Department of Obstetrics and Gynecology ; Wayne State University ; Detroit , MI USA.
Michael D Pawlitza Department of Obstetrics and Gynecology ; Wayne State University ; Detroit , MI USA.
Bo Peia Department of Obstetrics and Gynecology ; Wayne State University ; Detroit , MI USA.
Fayi Yaoa Department of Obstetrics and Gynecology ; Wayne State University ; Detroit , MI USA.
Kang Chena Department of Obstetrics and Gynecology ; Wayne State University ; Detroit , MI USA.

Funding

Human MAIT celis in airway mucosal immune responses to intracellular infectionsU01AI095776 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M. · 2011 to 2015
$8.9M
NIAID NIH HHS U01AI95776
6 · The paper itself

Abstract

Children in early infancy do not mount effective antibody responses to many vaccines against commons infectious pathogens, which results in a window of increased susceptibility or severity infections. In addition, vaccine-preventable infections are among the leading causes of morbidity in pregnant women. Immunization during pregnancy can generate maternal immune protection as well as elicit the production and transfer of antibodies cross the placenta and via breastfeeding to provide early infant protection. Several successful vaccines are now recommended to all pregnant women worldwide. However, significant gaps exist in our understanding of the efficacy and safety of other vaccines and in women with conditions associated with increased susceptible to high-risk pregnancies. Public acceptance of maternal immunization remained to be improved. Broader success of maternal immunization will rely on the integration of advances in basic science in vaccine design and evaluation and carefully planned clinical trials that are inclusive to pregnant women.

Indexed as

Immunity, Maternally-AcquiredFemaleHumansInfantInfant, NewbornPregnancyPregnancy Complications, InfectiousVaccinesVaccinesantibodyB cellclinical trialimmunizationinfectionmucosal immunityneonatal Fc receptorpregnancyvaccinevaccine safety

Identifiers

PMID26366844
PMCPMC4685701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.