Evidence map›Paper›PMID 26366811›Full record

ReviewEpigenomics2016

Regulatory RNAs and control of epigenetic mechanisms: expectations for cognition and cognitive dysfunction.

Anderson A Butler, William M Webb, Farah D Lubin

Abstract readReview
In one paragraph

Review in Epigenomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
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  8. Inhibition of the ATAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  9. The Pleiotropy ofInternational journal of molecular sciences · 2022
    Review
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  18. The Epigenetics of the Endocannabinoid System.International journal of molecular sciences · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anderson A ButlerDepartment of Neurobiology, University of Alabama at Birmingham, 1825 University Boulevard, Birmingham, AL 35294, USA.
William M WebbDepartment of Neurobiology, University of Alabama at Birmingham, 1825 University Boulevard, Birmingham, AL 35294, USA.
Farah D LubinDepartment of Neurobiology, University of Alabama at Birmingham, 1825 University Boulevard, Birmingham, AL 35294, USA.
University of Alabama at Birmingham · US

Funding

UAB MENTAL RETARDATION RESEARCH CENTER (MRRC)P30HD038985 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POZZO-MILLER, LUCAS D · 2000 to 2012
$8.6M
Chromatin remodeling mechanisms of gene transcription in memoryR01MH097909 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUBIN, FARAH DOMINIQUE · 2012 to 2016
$1.9M
Epigenetic Mechanisms of Gene Regulation in Long-Term Memory FormationR00MH082106 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUBIN, FARAH DOMINIQUE · 2009 to 2011
$737k
Chromatin Remodeling Mechanism of Gene Transcription in MemoryR56MH097909 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUBIN, FARAH DOMINIQUE · 2018 to 2018
$502k
Epigenetic Mechanisms in Epilepsy-Related Memory FormationR21NS090250 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUBIN, FARAH DOMINIQUE · 2015 to 2016
$404k
Epigenetic Mechanisms of Gene Regulation in Long-Term Memory FormationK99MH082106 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUBIN, FARAH DOMINIQUE · 2008 to 2008
$84k
NICHD NIH HHS P30 HD038985NICHD NIH HHS P30-HD38985NIMH NIH HHS K99 MH082106NIMH NIH HHS MH082106NIMH NIH HHS MH097909NIMH NIH HHS R00 MH082106NIMH NIH HHS R01 MH097909NIMH NIH HHS R56 MH097909NINDS NIH HHS R21 NS090250
6 · The paper itself

Abstract

The diverse functions of noncoding RNAs (ncRNAs) can influence virtually every aspect of the transcriptional process including epigenetic regulation of genes. In the CNS, regulatory RNA networks and epigenetic mechanisms have broad relevance to gene transcription changes involved in long-term memory formation and cognition. Thus, it is becoming increasingly clear that multiple classes of ncRNAs impact neuronal development, neuroplasticity, and cognition. Currently, a large gap exists in our knowledge of how ncRNAs facilitate epigenetic processes, and how this phenomenon affects cognitive function. In this review, we discuss recent findings highlighting a provocative role for ncRNAs including lncRNAs and piRNAs in the control of epigenetic mechanisms involved in cognitive function. Furthermore, we discuss the putative roles for these ncRNAs in cognitive disorders such as schizophrenia and Alzheimer's disease.

Indexed as

Epigenesis, GeneticAlzheimer DiseaseCognitionGene Regulatory NetworksHumansRNA, UntranslatedSchizophreniaRNA, Untranslatedchromatinepigeneticslong noncoding RNAneuroplasticityneuroscienceshort noncoding RNA

Identifiers

PMID26366811
PMCPMC5514977
OpenAlexW2153608813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.