ArticlePloS one2015
Assessing the Metabolic Diversity of Streptococcus from a Protein Domain Point of View.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Ten simple rules to complete successfully a computational MSc thesis project.PLoS computational biology · 2025Article
- Development of "Quadrello di Ovino", a Novel Fresh Ewe's Cheese.Foods (Basel, Switzerland) · 2021Article
- Applying PICRUSt and 16S rRNA functional characterisation to predicting co-digestion strategies of various animal manures for biogas production.Scientific reports · 2021Article
- Phenotype and multi-omics comparison of Staphylococcus and Streptococcus uncovers pathogenic traits and predicts zoonotic potential.BMC genomics · 2021Article
- Persistence of Functional Protein Domains in Mycoplasma Species and their Role in Host Specificity and Synthetic Minimal Life.Frontiers in cellular and infection microbiology · 2017Article
- Protein domain architectures provide a fast, efficient and scalable alternative to sequence-based methods for comparative functional genomics.F1000Research · 2016Article
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Authors and funding
5 authors.
Funding
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Abstract
Understanding the diversity and robustness of the metabolism of bacteria is fundamental for understanding how bacteria evolve and adapt to different environments. In this study, we characterised 121 Streptococcus strains and studied metabolic diversity from a protein domain perspective. Metabolic pathways were described in terms of the promiscuity of domains participating in metabolic pathways that were inferred to be functional. Promiscuity was defined by adapting existing measures based on domain abundance and versatility. The approach proved to be successful in capturing bacterial metabolic flexibility and species diversity, indicating that it can be described in terms of reuse and sharing functional domains in different proteins involved in metabolic activity. Additionally, we showed striking differences among metabolic organisation of the pathogenic serotype 2 Streptococcus suis and other strains.
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