Evidence map›Paper›PMID 26366673›Full record

ReviewExpert review of vaccines2015

Current status and future prospects of yellow fever vaccines.

Andrew S Beck, Alan D T Barrett

Abstract readReview
In one paragraph

Review in Expert review of vaccines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. A Systematic Review on Yellow Fever Vaccine and Adverse Events.Global health, epidemiology and genomics · 2026
    Pooled it
  2. Article
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  7. Review
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  18. The Present and Future of Yellow Fever Vaccines.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andrew S Becka 1 Department of Pathology, University of Texas Medical Branch, Galveston TX 77555-0609, USA.
Alan D T Barrett
Schlumberger (Ireland) · IE

Funding

Biodefense Training ProgramT32AI060549 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ASHOK K CHOPRA, Janice J Endsley · 2004 to 2026
$3.0M
Next Generation sequencing of yellow fever 17D vaccine virusR21AI113407 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BARRETT, ALAN D.T. · 2015 to 2016
$426k
NIAID NIH HHS R21 AI 113407NIAID NIH HHS R21 AI113407NIAID NIH HHS T32 AI 060549NIAID NIH HHS T32 AI060549
6 · The paper itself

Abstract

Yellow fever 17D vaccine is one of the oldest live-attenuated vaccines in current use that is recognized historically for its immunogenic and safe properties. These unique properties of 17D are presently exploited in rationally designed recombinant vaccines targeting not only flaviviral antigens but also other pathogens of public health concern. Several candidate vaccines based on 17D have advanced to human trials, and a chimeric recombinant Japanese encephalitis vaccine utilizing the 17D backbone has been licensed. The mechanism(s) of attenuation for 17D are poorly understood; however, recent insights from large in silico studies have indicated particular host genetic determinants contributing to the immune response to the vaccine, which presumably influences the considerable durability of protection, now in many cases considered to be lifelong. The very rare occurrence of severe adverse events for 17D is discussed, including a recent fatal case of vaccine-associated viscerotropic disease.

Indexed as

Drug DiscoveryHumansJapanese Encephalitis VaccinesVaccines, AttenuatedVaccines, SyntheticYellow FeverYellow Fever VaccineJapanese Encephalitis VaccinesVaccines, AttenuatedVaccines, SyntheticYellow Fever Vaccineempiricempiric vaccineflaviviruslive-attenuatedprimary seedrational vaccinerecombinant vaccinesecondary seedvaccineviral diversityyellow fever virus

Identifiers

PMID26366673
PMCPMC5563254
OpenAlexW1840529379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.