Evidence map›Paper›PMID 26366540›Full record

ArticleAnnals of surgery2015

Factors Predicting Outcomes After a Total Pancreatectomy and Islet Autotransplantation Lessons Learned From Over 500 Cases.

Srinath Chinnakotla, Gregory J Beilman, Ty B Dunn, Melena D Bellin, Martin L Freeman, David M Radosevich, Mustafa Arain, Stuart K Amateau, J Shawn Mallery, Sarah J Schwarzenberg and 8 more

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. [Role of Surgical Treatment in Painful Chronic Pancreatitis].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2026
    Review
  6. Article
  7. Observational
  8. Surgical management of chronic pancreatitis: A narrative review.United European gastroenterology journal · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Clinical and Genetic Description of Hereditary Chronic Pancreatitis in Pakistani Children.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Srinath Chinnakotla*Department of Surgery, University of Minnesota Medical School, Minneapolis, MN †Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN ‡Schulze Diabetes Institute, University of Minnesota Medical School, Minneapolis, MN §Department of Medicine, University of Minnesota Medical School, Minneapolis, MN ¶Pain Management, University of Minnesota Medical School, Minneapolis, MN.
Gregory J Beilman
Ty B Dunn
Melena D Bellin
Martin L Freeman
David M Radosevich
Mustafa Arain
Stuart K Amateau
J Shawn Mallery
Sarah J Schwarzenberg
Alfred Clavel
Joshua Wilhelm
R Paul Robertson
Louise Berry
Marie Cook
Bernhard J Hering
David E R Sutherland
Timothy L Pruett

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
NCATS NIH HHS UL1 TR000114
6 · The paper itself

Abstract

objectiveOur objective was to analyze factors predicting outcomes after a total pancreatectomy and islet autotransplantation (TP-IAT).

backgroundChronic pancreatitis (CP) is increasingly treated by a TP-IAT. Postoperative outcomes are generally favorable, but a minority of patients fare poorly.

methodsIn our single-centered study, we analyzed the records of 581 patients with CP who underwent a TP-IAT. Endpoints included persistent postoperative "pancreatic pain" similar to preoperative levels, narcotic use for any reason, and islet graft failure at 1 year.

resultsIn our patients, the duration (mean ± SD) of CP before their TP-IAT was 7.1 ± 0.3 years and narcotic usage of 3.3 ± 0.2 years. Pediatric patients had better postoperative outcomes. Among adult patients, the odds of narcotic use at 1 year were increased by previous endoscopic retrograde cholangiopancreatography (ERCP) and stent placement, and a high number of previous stents (>3). Independent risk factors for pancreatic pain at 1 year were pancreas divisum, previous body mass index >30, and a high number of previous stents (>3). The strongest independent risk factor for islet graft failure was a low islet yield-in islet equivalents (IEQ)-per kilogram of body weight. We noted a strong dose-response relationship between the lowest-yield category (<2000 IEQ) and the highest (≥5000 IEQ or more). Islet graft failure was 25-fold more likely in the lowest-yield category.

conclusionsThis article represents the largest study of factors predicting outcomes after a TP-IAT. Preoperatively, the patient subgroups we identified warrant further attention.

Indexed as

Islets of Langerhans TransplantationPancreatectomyAdolescentAdultAgedChildChild, PreschoolFemaleGraft SurvivalHumansMaleMiddle AgedNarcoticsPancreatitis, ChronicPostoperative PainRetrospective StudiesNarcotics

Identifiers

PMID26366540
PMCPMC5554067

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.