ReviewBritish journal of clinical pharmacology2016
Pharmacological treatment of organophosphorus insecticide poisoning: the old and the (possible) new.
Review in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 179 citations in OpenAlex.
- Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial.Lancet (London, England) · 2017Trial
- A Sustainable Treatment Protocol for Organophosphate Poisoning in Rural Kenya for Facilities without Intensive Care Units and Where Transfer Is Not Possible.The American journal of tropical medicine and hygiene · 2026Article
- Nanotechnology-based detoxification of profenofos using red blood cell membrane-coated polymeric nanoparticles.BMC pharmacology & toxicology · 2026Article
- Challenges and advances in the development of antidotes against A-series nerve agents.Archives of toxicology · 2026Review
- Organophosphate pesticides: a review on classification, synthesis, toxicity, remediation and analysis.RSC advances · 2025Review
- Nanodiamond mediated delivery of pyridinium oxime antidotes to central nervous system for potential treatment of exposure to nerve agents.Chemico-biological interactions · 2025Article
- Neurocognitive and neurobiological effects of low dose organophosphate exposure.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Article
- The key role of magnesium sulfate in the management of organophosphorus pesticide poisoning: a scoping literature review.Clinical and experimental emergency medicine · 2025Article
- Case Report: 2-PAM or not 2-PAM.Clinical practice and cases in emergency medicine · 2025Article
- Protective effects of lipid emulsion on vital organs through the LPS/TLR4 pathway in acute organophosphate poisoning.BMC pharmacology & toxicology · 2025Article
- Role of paraoxonase 1 in organophosphate G-series nerve agent poisoning and future therapeutic strategies.Archives of toxicology · 2025Review
- Situational analysis of pesticide poisoning and perceptions of autoinjector devices in rural communities in Sri Lanka - a study protocol.Global health action · 2024Article
- Reactivation by novel pyridinium oximes of rat serum and skeletal muscle acetylcholinesterase inhibited by organophosphates.Journal of biochemical and molecular toxicology · 2024Article
- Screening of efficient salicylaldoxime reactivators for DFP and paraoxon-inhibited acetylcholinesterase.RSC medicinal chemistry · 2024Article
- Albuterol as an adjuvant in acute anticholinesterase pesticide poisoning: a randomized, placebo-controlled clinical trial.Toxicology research · 2024Article
- Comparative analysis of organophosphorus versus carbamate pesticide poisoning: a case study.Arhiv za higijenu rada i toksikologiju · 2024Article
- Navigating the Neurological Abyss: A Comprehensive Review of Organophosphate Poisoning Complications.Cureus · 2024Review
- Organophosphate Poisoning: Review of Prognosis and Management.Advanced biomedical research · 2024Review
- Comparative Analysis of Outcomes in Acute Organophosphate Poisoning With and Without N-acetyl Cysteine Intervention.Cureus · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Despite being a major clinical and public health problem across the developing world, responsible for at least 5 million deaths over the last three decades, the clinical care of patients with organophosphorus (OP) insecticide poisoning has little improved over the last six decades. We are still using the same two antidotes - atropine and oximes - that first came into clinical use in the late 1950s. Clinical research in South Asia has shown how improved regimens of atropine can prevent deaths. However, we are still unsure about which patients are most likely to benefit from the use of oximes. Supplemental antidotes, such as magnesium, clonidine and sodium bicarbonate, have all been proposed and studied in small trials without production of definitive answers. Novel antidotes such as nicotinic receptor antagonists, beta-adrenergic agonists and lipid emulsions are being studied in large animal models and in pilot clinical trials. Hopefully, one or more of these affordable and already licensed antidotes will find their place in routine clinical care. However, the large number of chemically diverse OP insecticides, the varied poisoning they produce and their varied response to treatment might ultimately make it difficult to determine definitively whether these antidotes are truly effective. In addition, the toxicity of the varied solvents and surfactants formulated with the OP active ingredients complicates both treatment and studies. It is possible that the only effective way to reduce deaths from OP insecticide poisoning will be a steady reduction in their agricultural use worldwide.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.