ArticleBioMed research international2015
Optimization of Fermentation Medium for Extracellular Lipase Production from Aspergillus niger Using Response Surface Methodology.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Biosourcing and optimization of fungal lipase production from cheap agro waste via solid state fermentation.Scientific reports · 2025Article
- Optimization of triterpenoids biosynthesis in Athelia termitophila as a source of natural products.AMB Express · 2025Article
- Preparation ofFood science and biotechnology · 2022Article
- Investigation of Lipolytic-Secreting Bacteria from an Artificially Polluted Soil Using a Modified Culture Method and Optimization of Their Lipase Production.Microorganisms · 2021Article
- Production strategies and biotechnological relevance of microbial lipases: a review.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Review
- Production, purification, characterization, and biological properties of Rhodosporidium paludigenum polysaccharide.PloS one · 2021Article
- Enhancement of Aeribacillus pallidus strain VP3 lipase catalytic activity through optimization of medium composition using Box-Behnken design and its application in detergent formulations.Environmental science and pollution research international · 2020Article
- Optimization of submerged culture conditions involving a developed fine powder solid seed for exopolysaccharide production by the medicinal mushroomFood science and biotechnology · 2019Article
- Optimization of Submerged Fermentation Medium for Matrine Production byMycobiology · 2017Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipase produced by Aspergillus niger is widely used in various industries. In this study, extracellular lipase production from an industrial producing strain of A. niger was improved by medium optimization. The secondary carbon source, nitrogen source, and lipid were found to be the three most influential factors for lipase production by single-factor experiments. According to the statistical approach, the optimum values of three most influential parameters were determined: 10.5 g/L corn starch, 35.4 g/L soybean meal, and 10.9 g/L soybean oil. Using this optimum medium, the best lipase activity was obtained at 2,171 U/mL, which was 16.4% higher than using the initial medium. All these results confirmed the validity of the model. Furthermore, results of the Box-Behnken Design and quadratic models analysis indicated that the carbon to nitrogen (C/N) ratio significantly influenced the enzyme production, which also suggested that more attention should be paid to the C/N ratio for the optimization of enzyme production.
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