Evidence map›Paper›PMID 26366304›Full record

ReviewNeural plasticity2015

Neural Plasticity in Common Forms of Chronic Headaches.

Tzu-Hsien Lai, Ekaterina Protsenko, Yu-Chen Cheng, Marco L Loggia, Gianluca Coppola, Wei-Ta Chen

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neural plasticity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04578782 (Pilot Study for the Evaluation of the Efficacy of OnabotulinumtoxinA in High Frequency Migraine), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04578782 phase2completednot on this mapstarted 2018, after this paper: background citation

Pilot Study for the Evaluation of the Efficacy of OnabotulinumtoxinA in High Frequency Migraine

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2018 to 2020Enrolled32ConditionsMigraineArmsOnabotulinumtoxinA
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. The fifth cranial nerve in headaches.The journal of headache and pain · 2020
    Review
  11. Article
  12. Review
  13. Article
  14. Perivascular neurotransmitters: Regulation of cerebral blood flow and role in primary headaches.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Pain Perception and Migraine.Frontiers in neurology · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Tzu-Hsien LaiDepartment of Neurology, National Yang-Ming University School of Medicine, Taipei 112, Taiwan ; Section of Neurology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan.
Ekaterina ProtsenkoMGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Yu-Chen ChengDepartment of Neurology, National Yang-Ming University School of Medicine, Taipei 112, Taiwan ; Section of Neurology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan.
Marco L LoggiaMGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Gianluca CoppolaDepartment of Neurophysiology of Vision and Neurophthalmology, G.B. Bietti Foundation-IRCCS, 00198 Rome, Italy.
Wei-Ta ChenDepartment of Neurology, National Yang-Ming University School of Medicine, Taipei 112, Taiwan ; Institute of Brain Science, National Yang-Ming University School of Medicine, Taipei 112, Taiwan ; Neurological Institute, Taipei Veterans General Hospital, Taipei 112, Taiwan.
National Yang Ming Chiao Tung University · TWHarvard University · USFondazione G.B. Bietti · IT

Funding

The Role of Neuroimmune Activation in Chronic Pain and Negative AffectR21NS087472 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO · 2014 to 2015
$479k
NINDS NIH HHS R21 NS087472
6 · The paper itself

Abstract

Headaches are universal experiences and among the most common disorders. While headache may be physiological in the acute setting, it can become a pathological and persistent condition. The mechanisms underlying the transition from episodic to chronic pain have been the subject of intense study. Using physiological and imaging methods, researchers have identified a number of different forms of neural plasticity associated with migraine and other headaches, including peripheral and central sensitization, and alterations in the endogenous mechanisms of pain modulation. While these changes have been proposed to contribute to headache and pain chronification, some findings are likely the results of repetitive noxious stimulation, such as atrophy of brain areas involved in pain perception and modulation. In this review, we provide a narrative overview of recent advances on the neuroimaging, electrophysiological and genetic aspects of neural plasticity associated with the most common forms of chronic headaches, including migraine, cluster headache, tension-type headache, and medication overuse headache.

Indexed as

Neuronal PlasticityElectrophysiological PhenomenaHeadache DisordersHumansNeuroimaging

Identifiers

PMID26366304
PMCPMC4558449
OpenAlexW1763475520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.