ArticleJournal of pathogens2015
Prevalence of Virulence Factors and Drug Resistance in Clinical Isolates of Enterococci: A Study from North India.
Article in Journal of pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Global Prevalence of Vancomycin-Resistant Enterococcus faecium and Enterococcus faecalis Isolated From Clinical and Environmental Sources: A Systematic Review and Meta-Analysis.MicrobiologyOpen · 2026Pooled it
- The global prevalence of biofilm-forming Enterococcus faecalis in clinical isolates: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Article
- Molecular Characterization of Vancomycin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Polidocanol inhibits Enterococcus faecalis virulence factors by targeting fsr quorum sensing system.BMC microbiology · 2024Article
- Antibiotic Susceptibility Patterns and Virulence-Associated Factors of Vancomycin-Resistant Enterococcal Isolates from Tertiary Care Hospitals.Antibiotics (Basel, Switzerland) · 2023Article
- Enterococci as Intestinal Microbiota: Investigation of Characteristics and Probiotic Potential in Isolates from Adults and Breast-Fed Infants.Probiotics and antimicrobial proteins · 2022Article
- Antibiogram Pattern and Virulence Trait Characterization ofJournal of laboratory physicians · 2022Article
- Coupling the high-resolution LC-MS characterisation of the phenolic compounds with the antimicrobial and antibiofilm properties of helencha (Journal of food science and technology · 2021Article
- Synergistic Effect of Plant Extracts on Endodontic Pathogens Isolated from Teeth with Root Canal Treatment Failure: An In Vitro Study.Antibiotics (Basel, Switzerland) · 2021Article
- Improved detection of esp, hyl, asa1, gelE, cylA virulence genes among clinical isolates of Enterococci.BMC research notes · 2020Article
- Prevalence and phenotypic characterization of Enterococcus species isolated from clinical samples of pediatric patients in Jimma University Specialized Hospital, south west Ethiopia.BMC research notes · 2018Article
- Outbreak report: a nosocomial outbreak of vancomycin resistantAntimicrobial resistance and infection control · 2018Article
- Occurrence of vancomycin-resistant and -susceptible Enterococcus spp. in reclaimed water used for spray irrigation.Environmental research · 2016Article
- Prevalence and risk factors of early fecal carriage of Enterococcus faecalis and Staphylococcus spp and their antimicrobial resistant patterns among healthy neonates born in a hospital setting in central Saudi Arabia.Saudi medical journal · 2016Article
- A systematic review and meta-analysis on the prevalence of vancomycin-resistant enterococci (VRE) among Nigerians.Porto biomedical journalReview
- Susceptibility Pattern of Enterococci at Tertiary Care Hospital.Journal of global infectious diseasesArticle
- State of Globe: Enterococci: Virulence Factors and Biofilm Formation.Journal of global infectious diseasesArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Along with emergence of multidrug resistance, presence of several virulence factors in enterococci is an emerging concept. This study was undertaken to determine the prevalence of various virulence factors phenotypically and genotypically in enterococci and study their association with multidrug resistance. A total of 310 enterococcal isolates were studied, comprising 155 E. faecium and 155 E. faecalis. Antimicrobial susceptibility testing was done by disc diffusion and agar dilution method. Hemolysin, gelatinase, biofilm production, and haemagglutination were detected phenotypically and presence of virulence genes, namely, asa1, gelE, cylA, esp, and hyl, was detected by multiplex PCR. Of the total, 47.41% isolates were high level gentamicin resistant (HLGRE) and 7.09% were vancomycin resistant (VRE). All the virulence traits studied were found in varying proportions, with majority in E. faecalis (p > 0.05). Strong biofilm producers possessed either asa1 or gelE gene. gelE silent gene was detected in 41.37% (12/29). However, increase in resistance was associated with significant decrease in expression or acquisition of virulence genes. Further, acquisition of vancomycin resistance was the significant factor responsible for the loss of virulence traits. Though it is presumed that increased drug resistance correlates with increased virulence, acquisition of vancomycin resistance might be responsible for reduced expression of virulence traits to meet the "biological cost" relating to VRE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.