Evidence map›Paper›PMID 26366299›Full record

ArticleJournal of aging research2015

Genetic Risk Score Predicts Late-Life Cognitive Impairment.

Mariegold E Wollam, Andrea M Weinstein, Judith A Saxton, Lisa Morrow, Beth Snitz, Nicole R Fowler, Barbara L Suever Erickson, Kathryn A Roecklein, Kirk I Erickson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of aging research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Genetics of Aggression in Alzheimer's Disease (AD).Frontiers in aging neuroscience · 2017
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mariegold E WollamDepartment of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USA.
Andrea M WeinsteinDepartment of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USA ; Center for the Neural Basis of Cognition, University of Pittsburgh, 4400 Fifth Avenue, Suite 115, Pittsburgh, PA 15213, USA.
Judith A SaxtonDepartment of Neurology, University of Pittsburgh, 811 Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
Lisa MorrowDepartment of Psychiatry, University of Pittsburgh, Thomas Detre Hall, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
Beth SnitzDepartment of Neurology, University of Pittsburgh, 811 Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
Nicole R FowlerDivision of General Internal Medicine and Geriatrics, Indiana University, Fifth Third Faculty Building, 720 Eskenazi Avenue, Indianapolis, IN 46202, USA.
Barbara L Suever EricksonDepartment of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USA.
Kathryn A RoeckleinDepartment of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USA ; Center for the Neural Basis of Cognition, University of Pittsburgh, 4400 Fifth Avenue, Suite 115, Pittsburgh, PA 15213, USA.
Kirk I EricksonDepartment of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260, USA ; Center for the Neural Basis of Cognition, University of Pittsburgh, 4400 Fifth Avenue, Suite 115, Pittsburgh, PA 15213, USA.
University of Pittsburgh · USCenter for the Neural Basis of Cognition · USIndiana University – Purdue University Indianapolis · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
University of Pittsburgh Clinical and Translational Science InstitutionKL2TR000146 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$8.7M
Cognitive Assessment of Elderly Primary Care Patients.R01AG023129 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SAXTON, JUDITH A · 2005 to 2010
$3.1M
Influence of Physical Activity and Weight Loss on Brain PlasticityR01DK095172 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2012 to 2016
$2.1M
NCATS NIH HHS KL2 TR000146NCATS NIH HHS UL1 TR000005NIA NIH HHS R01 AG023129NIDDK NIH HHS R01 DK095172
6 · The paper itself

Abstract

Introduction. A family history of Alzheimer's disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods. In a sample of 95 older adults (Mean age = 75.1, 64.2% female), we constructed a genetic risk score based on the accumulation of risk alleles in BDNF, COMT, and APOE. A neuropsychological evaluation and consensus determined cognitive status (44 nonimpaired, 51 impaired). Logistic regression was performed to determine whether the genetic risk score predicted cognitive impairment above and beyond that associated with each gene. Results. An increased genetic risk score was associated with a nearly 4-fold increased risk of cognitive impairment (OR = 3.824, P = .013) when including the individual gene polymorphisms as covariates in the model. Discussion. A risk score combining multiple genetic influences may be more useful in predicting late-life cognitive impairment than individual polymorphisms.

Identifiers

PMID26366299
PMCPMC4561094
OpenAlexW1637385344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.