Evidence map›Paper›PMID 26366231›Full record

ArticleCellular and molecular bioengineering2015

Design of a Novel 3D Printed Bioactive Nanocomposite Scaffold for Improved Osteochondral Regeneration.

Nathan J Castro, Romil Patel, Lijie Grace Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular bioengineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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  8. Review
  9. Applications of nanotechnology in 3D printed tissue engineering scaffolds.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2021
    Review
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  16. Advances in three-dimensional bioprinting for hard tissue engineering.Tissue engineering and regenerative medicine · 2016
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nathan J CastroDepartment of Mechanical and Aerospace Engineering, The George Washington University, 800 22 street, NW, Washington, DC, 20052.
Romil PatelDepartment of Biomedical Engineering, The George Washington University, 800 22 street, NW, Washington, DC, 20052.
Lijie Grace ZhangDepartment of Mechanical and Aerospace Engineering, The George Washington University, 800 22 street, NW, Washington, DC, 20052 ; Department of Biomedical Engineering, The George Washington University, 800 22 street, NW, Washington, DC, 20052 ; Department of Medicine, The George Washington University, 800 22 street, NW, Washington, DC, 20052.

Funding

A Novel 3D Bioprinted Smart Vascularized Nano TissueDP2EB020549 · NIBIB · GEORGE WASHINGTON UNIVERSITY · PI ZHANG, LIJIE GRACE · 2014 to 2014
$2.3M
NIBIB NIH HHS DP2 EB020549
6 · The paper itself

Abstract

Chronic and acute osteochondral defects as a result of osteoarthritis and trauma present a common and serious clinical problem due to the tissue's inherent complexity and poor regenerative capacity. In addition, cells within the osteochondral tissue are in intimate contact with a 3D nanostructured extracellular matrix composed of numerous bioactive organic and inorganic components. As an emerging manufacturing technique, 3D printing offers great precision and control over the microarchitecture, shape and composition of tissue scaffolds. Therefore, the objective of this study is to develop a biomimetic 3D printed nanocomposite scaffold with integrated differentiation cues for improved osteochondral tissue regeneration. Through the combination of novel nano-inks composed of organic and inorganic bioactive factors and advanced 3D printing, we have successfully fabricated a series of novel constructs which closely mimic the native 3D extracellular environment with hierarchical nanoroughness, microstructure and spatiotemporal bioactive cues. Our results illustrate several key characteristics of the 3D printed nanocomposite scaffold to include improved mechanical properties as well as excellent cytocompatibility for enhanced human bone marrow-derived mesenchymal stem cell adhesion, proliferation, and osteochondral differentiation

Indexed as

3D printingbioactivebiomimeticgrowth factor deliverynanocompositeosteochondralstem cell

Identifiers

PMID26366231
PMCPMC4564127

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.