ArticlePostepy dermatologii i alergologii2015
Prevalence of IgE-mediated allergy and evaluation of Th1/Th2 cytokine profiles in patients with severe bronchial asthma.
Article in Postepy dermatologii i alergologii, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Evaluation of a translational swine model of respiratory hypersensitivity induced by exposure toFrontiers in allergy · 2025Article
- Lncrna NEAT1 Regulates Th1/Th2 in Pediatric Asthma by Targeting MicroRNA-217/GATA3.Iranian journal of public health · 2023Article
- Resveratrol in the treatment of asthma based on an animal model.Postepy dermatologii i alergologii · 2022Review
- The Emerging Roles of T Helper Cell Subsets and Cytokines in Severe Neutrophilic Asthma.Inflammation · 2022Article
- C-KitIranian journal of basic medical sciences · 2022Article
- The expression and function of programmed death-ligand 1 and related cytokines in neutrophilic asthma.Annals of translational medicine · 2021Article
- Synergistic effect of Korean red ginseng extract and GABA mixture on the IgE production in mice via Th1/Th2 cell balance.Food science and biotechnology · 2021Article
- The Immunological Association between Alopecia Areata and Respiratory Diseases: A Systematic Review.Skin appendage disorders · 2019Article
- Chinese expert consensus on diagnosis and management of severe asthma.Journal of thoracic disease · 2018Review
- The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review.Frontiers in immunology · 2018Review
- Jinkui Shenqi Pills Ameliorate Asthma with "Kidney Yang Deficiency" by Enhancing the Function of the Hypothalamic-Pituitary-Adrenal Axis to Regulate T Helper 1/2 Imbalance.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Effects of the combined extracts of Herba Epimedii and Fructus Ligustrilucidi on airway remodeling in the asthmatic rats with the treatment of budesonide.BMC complementary and alternative medicine · 2017Article
- Early-life gut microbial colonization shapes Th1/Th2 balance in asthma model in BALB/c mice.BMC microbiology · 2017Article
- Effects of salbutamol aerosol combined with magnesium sulfate on T-lymphocyte subgroup and Th1/Th2 cytokines of pediatric asthma.Experimental and therapeutic medicine · 2017Article
- Impact of allergy and atopy on the risk of pseudophakic cystoid macular edema.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
- Can mean platelet volume be used as a biomarker for asthma?Postepy dermatologii i alergologii · 2016Article
- Selected CC and CXC chemokines in children with atopic asthma.Postepy dermatologii i alergologii · 2016Article
- Relationships between Th1/Th2 cytokine profiles and chest radiographic manifestations in childhoodTherapeutics and clinical risk management · 2016Article
- The therapeutic potential ofAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe pathogenesis of asthma remains unclear, especially in cases of the severe disease.
aimTo explore IgE-mediated inhalant sensitization in severe asthma compared with a group of patients with chronic mild disease and evaluate the Th1/Th2 cytokine profiles in asthma by different disease severities. MATERIAL AND
methodsOne hundred and fifty-four patients (age range: 28-69) with severe chronic asthma (study group) and 141 patients with chronic mild disease (control group) diagnosed according to GINA criteria were included in the study. Seventy-eight severe asthmatics and 43 subjects with mild disease were randomly selected for serum Th1/Th2 cytokine level estimation. The groups were matched in terms of age and atopy features (skin prick tests, specific and total serum IgE).
resultsPositive skin tests to at least one allergen were observed with comparable frequencies. Sensitization to Dermatophagoides pteronyssinus was the most prevalent positive result in both groups. An earlier onset of asthma together with a greater number of exacerbations was noted in severe asthmatics compared to patients with mild disease. Serum levels of interleukin 4 and 2 (IL-4 and IL-2) were detectable only in severe asthmatics irrespective of atopy features. The levels of interferon γ and tumour necrosis factor α were undetectable in both groups. IL-10 and IL-5 were detected in the serum of only 7 and 12 severe asthmatics, respectively.
conclusionsThe serum level of IL-2 and IL-4 could be perceived as a marker of severe asthma. Neither IL-2 nor IL-4 levels in the serum could differentiate allergic and non-allergic asthma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.