ArticleMetabolomics : Official journal of the Metabolomic Society
Serially coupling hydrophobic interaction and reversed-phase chromatography with simultaneous gradients provides greater coverage of the metabolome.
Article in Metabolomics : Official journal of the Metabolomic Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Combined RP-HILIC for suspect screening of persistent, mobile, and toxic substances in surface water: A case study.Scientific reports · 2025Article
- Comparative evaluation of comprehensive offline 2D-LC strategies coupled to MS for untargeted metabolomic studies of human urine.Analytical and bioanalytical chemistry · 2025Article
- Can plant hormonomics be built on simple analysis? A review.Plant methods · 2023Review
- Isoniazid derivatization strategy of carboxyl-containing metabolites for LC-MS/MS-based targeted metabolomics.Analytical and bioanalytical chemistry · 2023Article
- Development of a dual-electrospray ionization source with in-line absorbance-based voltage control.Analytical and bioanalytical chemistry · 2023Article
- Implementation of a Dual-Column Liquid Chromatography-Tandem Mass-Spectrometry Method for the Quantification of Isavuconazole in Clinical Practice.Journal of laboratory physicians · 2021Article
- Liquid Chromatography-Mass Spectrometry for Clinical Metabolomics: An Overview.Advances in experimental medicine and biology · 2021Article
- Simultaneous determination of hydrophilic and lipophilic constituents in herbal medicines using directly-coupled reversed-phase and hydrophilic interaction liquid chromatography-tandem mass spectrometry.Scientific reports · 2017Article
- Improving the Sensitivity, Resolution, and Peak Capacity of Gradient Elution in Capillary Liquid Chromatography with Large-Volume Injections by Using Temperature-Assisted On-Column Solute Focusing.Analytical chemistry · 2016Article
- Advantages and Pitfalls of Mass Spectrometry Based Metabolome Profiling in Systems Biology.International journal of molecular sciences · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The serial coupling of a reversed-phase liquid chromatography (RPLC) column to a hydrophilic interaction liquid chromatography (HILIC) column has been developed in recent years for the detection of polar and nonpolar metabolites. TCA intermediates, bile acid standards and numerous polar and non-polar metabolites extracted from beer were analysed using a combined RPLC/HILIC method. Non-polar metabolites were retained by the RPLC column. Polar metabolites not retained by the RPLC column were retained and separated by the HILIC column. The results from this study validate this simple yet powerful metabolomics approach.
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Registered trials
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