ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Perirhinal Cortex mGlu5 Receptor Activation Reduces Relapse to Methamphetamine Seeking by Restoring Novelty Salience.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Activation of mGlu2 Receptors Rescues Persistent Post-Methamphetamine Deficit in Object-in-Place Recognition Memory.Brain sciences · 2026Article
- Perirhinal cortex to the nucleus accumbens circuit in novelty salience following methamphetamine self-administration.Addiction neuroscience · 2024Article
- Sex differences in behavior, cognitive, and physiological recovery following methamphetamine administration.Psychopharmacology · 2024Article
- Exercise Influences the Brain's Metabolic Response to Chronic Cocaine Exposure in Male Rats.Journal of personalized medicine · 2024Article
- Perirhinal to prefrontal circuit in methamphetamine induced recognition memory deficits.Neuropharmacology · 2023Article
- mGlu5 function in the nucleus accumbens core during the incubation of methamphetamine craving.Neuropharmacology · 2021Article
- Complex Interactions Between Sex and Stress on Heroin Seeking.Frontiers in neuroscience · 2021Article
- Neural mechanisms underlying incubation of methamphetamine craving: A mini-review.Pharmacology, biochemistry, and behavior · 2020Review
- Effects of Methamphetamine Self-Administration and Extinction on Astrocyte Structure and Function in the Nucleus Accumbens Core.Neuroscience · 2019Article
- Chemogenetic activation of the perirhinal cortex reverses methamphetamine-induced memory deficits and reduces relapse.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Effect of Novel Allosteric Modulators of Metabotropic Glutamate Receptors on Drug Self-administration and Relapse: A Review of Preclinical Studies and Their Clinical Implications.Biological psychiatry · 2018Review
- Methamphetamine self-administration modulates glutamate neurophysiology.Brain structure & function · 2017Article
- Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.Neuropharmacology · 2017Article
- AMPA Receptor Plasticity in Accumbens Core Contributes to Incubation of Methamphetamine Craving.Biological psychiatry · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Rats that have self-administered methamphetamine (meth) under long access, but not short access, conditions do not recognize novel objects. The perirhinal cortex is critical for novelty detection, and perirhinal metabotropic glutamate 5 receptors (mGlu5) are downregulated after long-access meth. The novel positive allosteric modulator (PAM) 1-(4-(2,4-difluorophenyl) piperazin-1-yl)-2-((4-fluorobenzyl)oxy)-ethanone, or DPFE, demonstrates improved solubility compared with other mGlu5 PAMs, thus allowing brain-site-specific pharmacological studies. Infusion of DPFE into perirhinal cortex restored novel object recognition in long-access meth rats. To investigate the impact of these cognitive enhancing effects on relapse, we tested the effects of DPFE infusions into perirhinal cortex on meth-seeking under two different test conditions. In the standard cue relapse test, perirhinal DPFE infusions did not alter meth-seeking in the presence of meth cues. However, in a novel cue relapse test, wherein animals were allowed to allocate responding between a novel cue and meth-conditioned cue, perirhinal DPFE infusions shifted the pattern of responding in long-access rats toward a profile resembling short-access rats, which respond equally for novel and meth cues. Perirhinal mGlu5 are thus a promising pharmacological target for the restoration of cognitive function in meth addicts. Targeting these receptors may also reduce relapse, particularly in situations where novel stimuli compete with conditioned stimuli for control over meth seeking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.